{"id":"W4404360296","doi":"10.1161/circ.150.suppl_1.4141912","title":"Abstract 4141912: Targeting NEK2 to Induce Senescence and DNA Damage in Pulmonary Arterial Hypertension","year":2024,"lang":"en","type":"article","venue":"Circulation","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Medicine; Senescence; DNA damage; Pulmonary hypertension; Cardiology; Internal medicine; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004194203,0.0005909326,0.0009406565,0.000521735,0.0003305486,0.0008511069,0.0003760583,0.000514031,0.004163738],"category_scores_gemma":[0.000263906,0.0002005426,0.0005734436,0.0006504079,0.0001996838,0.0003724829,0.0004195359,0.0009965422,0.001719248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004931834,"about_ca_system_score_gemma":0.0006744215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006179732,"about_ca_topic_score_gemma":0.001255623,"domain_scores_codex":[0.9996729,0.00002583868,0.00003221333,0.0001016417,0.0001154635,0.0000519788],"domain_scores_gemma":[0.9998266,0.00002219205,0.00004836662,0.00002114537,0.00003260015,0.00004899558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002478419,0.0003546048,0.002051631,0.0009807269,0.0001809666,0.0001313377,0.00003704444,0.001236397,0.9622722,0.0002456116,0.007095309,0.02293572],"study_design_scores_gemma":[0.000894946,0.004011669,0.03728279,0.0001638875,0.0004659144,0.00106099,0.0001310104,0.01056431,0.8590561,0.000724757,0.08556165,0.00008198553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8706794,0.02604828,0.01160962,0.001521832,0.0009625412,0.0005040828,0.0775248,0.002854195,0.008295231],"genre_scores_gemma":[0.8208721,0.01102487,0.01118507,0.001160918,0.0002076835,0.0008708636,0.1410335,0.0003628768,0.01328226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004163738,"threshold_uncertainty_score":0.01392913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03399020030863471,"score_gpt":0.2920787270136834,"score_spread":0.2580885267050487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}