{"id":"W4404360519","doi":"10.1016/j.jtct.2024.11.006","title":"Early Mixed Donor Chimerism is a Strong Negative Prognostic Indicator in Allogeneic Stem Cell Transplant for AML and MDS","year":2024,"lang":"en","type":"article","venue":"Transplantation and Cellular Therapy","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre; Juravinski Cancer Centre; Hamilton Health Sciences; Population Health Research Institute; McMaster University; Ontario Clinical Oncology Group","funders":"","keywords":"Stem cell; Immunology; Medicine; Oncology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001008316,0.0001431856,0.0002091593,0.0005404158,0.0002016163,0.0003405308,0.0002370551,0.0002563169,0.001231271],"category_scores_gemma":[0.002542758,0.0001145869,0.0001742467,0.0005078229,0.000276184,0.0002753539,0.000310122,0.00030503,0.0001951941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001482057,"about_ca_system_score_gemma":0.0002470305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003120792,"about_ca_topic_score_gemma":0.0005617052,"domain_scores_codex":[0.9996743,0.0001064319,0.00005411632,0.00004736884,0.00008000528,0.00003777841],"domain_scores_gemma":[0.9976552,0.0005531306,0.00126936,0.00009306583,0.00014871,0.0002806718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002593134,0.000010448,0.9973018,0.000008050537,0.00001148097,0.0001314529,0.00001339522,0.00004270186,0.0002508235,0.00001075177,0.00002942344,0.00193041],"study_design_scores_gemma":[0.000009103984,0.0002327731,0.9959644,0.00001156233,0.0000531671,0.002532389,0.00007841844,0.0003916363,0.0003772527,0.00005762506,0.0002879133,0.000003765722],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991454,0.0004579302,0.0001169199,0.00002878109,0.00000357383,0.000003319161,0.00007322685,0.000002345233,0.0001685566],"genre_scores_gemma":[0.9996921,0.00008531367,0.00008517359,0.000006052377,0.00000920936,0.00000211576,0.00007963971,7.275799e-7,0.00003973975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001231271,"threshold_uncertainty_score":0.00533253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01929219418799843,"score_gpt":0.2556502732318202,"score_spread":0.2363580790438217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}