{"id":"W4404360519","doi":"10.1016/j.jtct.2024.11.006","title":"Early Mixed Donor Chimerism is a Strong Negative Prognostic Indicator in Allogeneic Stem Cell Transplant for AML and MDS","year":2024,"lang":"en","type":"article","venue":"Transplantation and Cellular Therapy","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre; Juravinski Cancer Centre; Hamilton Health Sciences; Population Health Research Institute; McMaster University; Ontario Clinical Oncology Group","funders":"","keywords":"Stem cell; Immunology; Medicine; Oncology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002418184,0.0002833619,0.0003603089,0.000260301,0.00007753204,0.0000689943,0.00005667824,0.0001726036,0.00004940121],"category_scores_gemma":[6.784707e-7,0.0002455781,0.00009269711,0.0001843699,0.00008432689,0.0001261173,0.00000175886,0.0001969491,0.00001016638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002322173,"about_ca_system_score_gemma":0.00008233628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006161195,"about_ca_topic_score_gemma":0.00001813386,"domain_scores_codex":[0.9984694,0.00008356669,0.0004192849,0.0004988536,0.000221099,0.0003078494],"domain_scores_gemma":[0.9993992,0.0002391932,0.00005363696,0.0001188676,0.00002435644,0.0001647063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005765819,0.0006083926,0.1005433,0.01200639,0.0007329157,0.0009662944,0.1743466,0.00001135601,0.6520825,0.001601069,0.00004916635,0.05128615],"study_design_scores_gemma":[0.0163576,0.00172553,0.1559084,0.001726046,0.0009042993,0.0003677951,0.00158421,0.002575995,0.8170004,0.0003284279,0.0007270324,0.0007943277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766757,0.004093801,0.01653715,0.0003409876,0.0001233959,0.001740365,0.0002299512,0.0000906526,0.0001679768],"genre_scores_gemma":[0.9910955,0.007329556,0.000659625,0.0001677133,0.00004760997,0.000227197,0.0002295157,0.00005518167,0.0001880823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1727624,"threshold_uncertainty_score":0.9999996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01929219418799843,"score_gpt":0.2556502732318202,"score_spread":0.2363580790438217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}