{"id":"W4404363211","doi":"10.1161/circ.150.suppl_1.4141341","title":"Abstract 4141341: Association of Polygenic Risk Scores with Aortic Valve Calcium: The Multi-Ethnic Study of Atherosclerosis (MESA)","year":2024,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiovascular Disease and Adiposity","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Medicine; Mesa; Cardiology; Internal medicine; Ethnic group; Coronary artery calcium; Atherosclerosis Risk in Communities; Polygenic risk score; Aortic valve; Disease; Genetics; Genotype; Single-nucleotide polymorphism; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004247272,0.0001029672,0.0002479593,0.00007807736,0.00005578798,0.00001524495,0.00005037622,0.00006927234,0.00002062144],"category_scores_gemma":[0.00007256172,0.00006967067,0.0003466228,0.0003508683,0.00002997787,0.0000780097,0.00001462189,0.0001596671,0.000007101734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008495694,"about_ca_system_score_gemma":0.00006978953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003621848,"about_ca_topic_score_gemma":0.00005787234,"domain_scores_codex":[0.9988371,0.0001034646,0.000271467,0.000199967,0.0004703146,0.0001177254],"domain_scores_gemma":[0.9992336,0.0001160408,0.0001720729,0.0003353458,0.00009555047,0.0000474097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0000451412,0.0003964715,0.9767932,0.0001489758,0.001894632,0.000001550881,0.001585037,0.0009238224,0.01435201,0.000007237158,0.00001130968,0.0038406],"study_design_scores_gemma":[0.001154448,0.00008936683,0.9915257,0.0001834053,0.00307113,0.000001937527,0.0003760095,0.002391502,0.001120502,0.00001335295,0.000003184787,0.00006952808],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960582,0.00228526,0.0007474447,0.00003878428,0.00008547137,0.000684566,0.00001753954,0.00004287684,0.00003991318],"genre_scores_gemma":[0.999756,0.00005690076,0.00002437542,0.000009740928,0.00007093726,0.00001931866,0.00001858747,0.0000197447,0.00002437464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01473242,"threshold_uncertainty_score":0.2841088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03709573629182675,"score_gpt":0.297780935887998,"score_spread":0.2606851995961713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}