{"id":"W4404363211","doi":"10.1161/circ.150.suppl_1.4141341","title":"Abstract 4141341: Association of Polygenic Risk Scores with Aortic Valve Calcium: The Multi-Ethnic Study of Atherosclerosis (MESA)","year":2024,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiovascular Disease and Adiposity","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Medicine; Mesa; Cardiology; Internal medicine; Ethnic group; Coronary artery calcium; Atherosclerosis Risk in Communities; Polygenic risk score; Aortic valve; Disease; Genetics; Genotype; Single-nucleotide polymorphism; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00256663,0.0006736976,0.0005838489,0.0008170946,0.0007281788,0.0009410985,0.0005725106,0.0009492632,0.002881675],"category_scores_gemma":[0.003342885,0.0004303607,0.0007977684,0.001829786,0.0003093474,0.0004483201,0.0007599964,0.001202928,0.0004396568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001281246,"about_ca_system_score_gemma":0.0002618583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003178035,"about_ca_topic_score_gemma":0.003123986,"domain_scores_codex":[0.9987827,0.0006467717,0.0001017656,0.0002558454,0.0001331201,0.00007977559],"domain_scores_gemma":[0.997058,0.0007676531,0.0009512437,0.0005596218,0.000215392,0.0004481186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003667228,0.00004105507,0.997305,0.00001406365,0.0004729927,0.00006405251,0.00004402428,0.00007391068,0.0004511194,0.00003477125,0.0002462748,0.0008859729],"study_design_scores_gemma":[0.00002522946,0.00008705829,0.9989207,0.000005341324,0.0001555801,0.0001511264,0.00002895558,0.0003453353,0.00004907698,0.00005794987,0.0001701736,0.000003491929],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958937,0.0004336249,0.0005983593,0.0002453443,0.0000271315,0.00001964814,0.002255015,0.00001892593,0.0005081581],"genre_scores_gemma":[0.9970693,0.0001432862,0.0006416554,0.00006526479,0.00007475969,0.00003757812,0.001503779,0.00001232562,0.0004520978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003178035,"threshold_uncertainty_score":0.01357383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03709573629182675,"score_gpt":0.297780935887998,"score_spread":0.2606851995961713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}