{"id":"W4404363692","doi":"10.1161/circ.150.suppl_1.4140244","title":"Abstract 4140244: In a Murine Model of Experimental Sepsis, Cardiac-Specific Jarid2 Knockdown is Associated With Improved Myocardial Function and Survival","year":2024,"lang":"en","type":"article","venue":"Circulation","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Medicine; Gene knockdown; Cardiac function curve; Cardiology; Sepsis; Internal medicine; Heart failure; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001594762,0.0001215955,0.0001395329,0.00005074197,0.00002664368,0.00002733417,0.00003796819,0.0001231204,0.00001179515],"category_scores_gemma":[0.0000185576,0.0001225301,0.00007308387,0.0001012709,0.00004303154,0.0000103789,0.00002703107,0.0000693668,0.000001233763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004670673,"about_ca_system_score_gemma":0.00006770128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002389225,"about_ca_topic_score_gemma":0.00000491806,"domain_scores_codex":[0.9992146,0.00003130236,0.0001755347,0.0003214311,0.000133858,0.0001232637],"domain_scores_gemma":[0.999684,0.00001372435,0.00005043001,0.0001612398,0.00004750983,0.0000431028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001400495,0.00005881993,0.02286804,0.00002174587,0.0001051142,0.000001462558,0.0001217506,0.002693756,0.9733524,0.0000453648,0.00007665753,0.0005147884],"study_design_scores_gemma":[0.001596206,0.0001759552,0.4274418,0.0001242447,0.00009553543,0.000001705405,0.0001424704,0.03968117,0.5299807,0.0002170721,0.000134387,0.0004086906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959271,0.002419161,0.0008892845,0.00001395067,0.000205609,0.0001858896,0.00007507953,0.0000216933,0.0002622306],"genre_scores_gemma":[0.9994582,0.00002388628,0.00003984029,0.00001620465,0.0001072468,0.00002389215,0.0002935216,0.00002444296,0.0000127702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4433717,"threshold_uncertainty_score":0.4996633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01770402927173686,"score_gpt":0.242928349910155,"score_spread":0.2252243206384181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}