{"id":"W4404363692","doi":"10.1161/circ.150.suppl_1.4140244","title":"Abstract 4140244: In a Murine Model of Experimental Sepsis, Cardiac-Specific Jarid2 Knockdown is Associated With Improved Myocardial Function and Survival","year":2024,"lang":"en","type":"article","venue":"Circulation","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Medicine; Gene knockdown; Cardiac function curve; Cardiology; Sepsis; Internal medicine; Heart failure; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002215722,0.0008262249,0.0006588717,0.0004362265,0.0003337675,0.0004701877,0.0003610878,0.0007333052,0.005882399],"category_scores_gemma":[0.0001147714,0.0003113081,0.0003988112,0.0002396032,0.0004859922,0.0004599798,0.0003055758,0.001471834,0.001470951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002922408,"about_ca_system_score_gemma":0.0002703876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002903845,"about_ca_topic_score_gemma":0.0004118911,"domain_scores_codex":[0.9997309,0.00002382937,0.00003692734,0.00007800983,0.00007656302,0.0000537933],"domain_scores_gemma":[0.9997314,0.00002005795,0.00009911569,0.00001897123,0.00002456914,0.0001058474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004603335,0.00007995015,0.0001090537,0.000134101,0.000008712818,0.00006460467,0.00001385619,0.00003742442,0.9978619,0.00008274466,0.0002448636,0.0009024706],"study_design_scores_gemma":[0.0002104019,0.001679722,0.004527154,0.00003775947,0.00005851052,0.0007157734,0.00006308126,0.000807578,0.9854382,0.0000963663,0.006350358,0.00001507484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9678831,0.00575228,0.01013302,0.001294659,0.0007064755,0.0002093039,0.00780133,0.0010228,0.005197101],"genre_scores_gemma":[0.9557036,0.00323889,0.009988738,0.000625107,0.0001920694,0.0005037949,0.007859492,0.0002706661,0.02161765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005882399,"threshold_uncertainty_score":0.01967865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01770402927173686,"score_gpt":0.242928349910155,"score_spread":0.2252243206384181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}