{"id":"W4404364169","doi":"10.1161/circ.150.suppl_1.4139367","title":"Abstract 4139367: A major uremic toxin indoxyl sulfate impairs macrophage efferocytosis and accelerates atherogenesis: a potential mechanism for cardiovascular risk in chronic kidney disease","year":2024,"lang":"en","type":"article","venue":"Circulation","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Medicine; Efferocytosis; Uremic toxins; Kidney disease; Disease; Mechanism (biology); Cardiorenal syndrome; Macrophage; Internal medicine; Pharmacology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002892932,0.0005021323,0.0007649153,0.0003450076,0.000223086,0.0004010301,0.0002885071,0.0004456808,0.002798062],"category_scores_gemma":[0.0001280548,0.0001551934,0.0006538682,0.000478783,0.0002262473,0.0002400148,0.0002416389,0.0007972266,0.0004121908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003432309,"about_ca_system_score_gemma":0.0005042607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008643826,"about_ca_topic_score_gemma":0.001091166,"domain_scores_codex":[0.999819,0.00002625032,0.00001689896,0.00003703103,0.00006215409,0.00003877393],"domain_scores_gemma":[0.9999118,0.000009468846,0.00003283918,0.000008706836,0.0000115311,0.000025702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001498215,0.0001724077,0.001701401,0.0004022935,0.0001361644,0.00009668248,0.00001540478,0.0002124408,0.9895147,0.0001556867,0.0006176953,0.005476962],"study_design_scores_gemma":[0.0004368227,0.00423086,0.06401859,0.00007290647,0.0005668454,0.0006338301,0.00006557895,0.00256939,0.9160758,0.0004463213,0.01084917,0.00003380638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979487,0.01065613,0.002746914,0.0007271674,0.0002234978,0.00007883137,0.004533732,0.0003219412,0.001224764],"genre_scores_gemma":[0.9836255,0.004956121,0.002507992,0.0005028871,0.0000838794,0.0001354173,0.005443626,0.00003140151,0.002713385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002798062,"threshold_uncertainty_score":0.009360433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01068189021848437,"score_gpt":0.2289665453287879,"score_spread":0.2182846551103035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}