{"id":"W4404367132","doi":"10.1016/j.bbalip.2024.159577","title":"Inducible global knockout of surfeit locus protein 4 in adult mice results in hypolipidemia, intestinal lipid accumulation, liver injury, and increased mortality","year":2024,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Liver injury; Lipid accumulation; Locus (genetics); Knockout mouse; Biology; Internal medicine; Endocrinology; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000261431,0.001033206,0.0005575285,0.001115231,0.0002156867,0.000370996,0.0004521075,0.0008718831,0.004183553],"category_scores_gemma":[0.0001627546,0.0004512409,0.0006734947,0.000383127,0.0006628386,0.0003607076,0.0005084242,0.001154355,0.00101389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003761658,"about_ca_system_score_gemma":0.0003069203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005246729,"about_ca_topic_score_gemma":0.0007515802,"domain_scores_codex":[0.9996417,0.00004235438,0.00005720309,0.00009950816,0.00007248609,0.00008683942],"domain_scores_gemma":[0.9995503,0.00002488089,0.0001922942,0.00003698509,0.00002479783,0.0001707302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003674707,0.00003248982,0.0003563951,0.00004279635,0.00001566391,0.0001048963,0.00001403347,0.00005380504,0.9977515,0.00008318394,0.00009117533,0.00108641],"study_design_scores_gemma":[0.0001807281,0.001635936,0.01992807,0.0000425683,0.000134621,0.001264855,0.0001367157,0.001429677,0.9694319,0.0002093693,0.005573308,0.00003224114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863691,0.001349445,0.006658188,0.0002614073,0.00009523688,0.00006092353,0.00272722,0.0007740065,0.001704394],"genre_scores_gemma":[0.9695567,0.001650329,0.006568142,0.000203506,0.00004498437,0.0003021965,0.0050309,0.0002795175,0.0163637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004183553,"threshold_uncertainty_score":0.01399541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01225001539904078,"score_gpt":0.3064992812077277,"score_spread":0.2942492658086869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}