{"id":"W4404374818","doi":"10.1158/1078-0432.ccr-24-1947","title":"Update on Pediatric Surveillance Recommendations for <i>PTEN</i> Hamartoma Tumor Syndrome, <i>DICER1-</i> Related Tumor Predisposition, and Tuberous Sclerosis Complex","year":2024,"lang":"en","type":"review","venue":"Clinical Cancer Research","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre; Hospital for Sick Children; University of Toronto","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Manchester Biomedical Research Centre; National Cancer Institute; National Institutes of Health; Department of Health and Social Care; National Institute for Health and Care Research","keywords":"PTEN; Tuberous sclerosis; Medicine; Multidisciplinary approach; Hamartoma; Genetic predisposition; Pediatrics; Oncology; Pathology; PI3K/AKT/mTOR pathway; Disease; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001763125,0.0005305556,0.001092583,0.003080514,0.0002984042,0.0009942657,0.001035999,0.001449338,0.008922307],"category_scores_gemma":[0.005969404,0.0003195395,0.001327103,0.00241063,0.0002709724,0.001393564,0.0007002765,0.001975437,0.003472383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001059494,"about_ca_system_score_gemma":0.002964963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004160952,"about_ca_topic_score_gemma":0.007887886,"domain_scores_codex":[0.9992055,0.0002328279,0.0001978483,0.00006185998,0.0002529151,0.00004903861],"domain_scores_gemma":[0.9971336,0.001214909,0.0004438893,0.00004341546,0.001032263,0.0001319086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006573992,0.00003541631,0.0005165163,0.01726731,0.0001344711,0.000255978,0.0001122045,0.0001908151,0.000344423,0.002490669,0.2730118,0.7055745],"study_design_scores_gemma":[0.00002430752,0.00002823018,0.001071008,0.01564176,0.0002424651,0.0008406158,0.00005558829,0.0000350198,0.00009669045,0.000620895,0.9813299,0.00001353959],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002459492,0.9825973,0.0004462025,0.008035208,0.002036829,0.00004757759,0.0007782893,0.00006788224,0.005744719],"genre_scores_gemma":[0.001118206,0.9899974,0.001231407,0.00377364,0.0008853605,0.0000644016,0.0009569442,0.00001205338,0.001960556],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008922307,"threshold_uncertainty_score":0.0298481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4323668482449535,"score_gpt":0.539893201562797,"score_spread":0.1075263533178434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}