{"id":"W4404374818","doi":"10.1158/1078-0432.ccr-24-1947","title":"Update on Pediatric Surveillance Recommendations for <i>PTEN</i> Hamartoma Tumor Syndrome, <i>DICER1-</i> Related Tumor Predisposition, and Tuberous Sclerosis Complex","year":2024,"lang":"en","type":"review","venue":"Clinical Cancer Research","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre; Hospital for Sick Children; University of Toronto","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Manchester Biomedical Research Centre; National Cancer Institute; National Institutes of Health; Department of Health and Social Care; National Institute for Health and Care Research","keywords":"PTEN; Tuberous sclerosis; Medicine; Multidisciplinary approach; Hamartoma; Genetic predisposition; Pediatrics; Oncology; Pathology; PI3K/AKT/mTOR pathway; Disease; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.009685979,0.001048837,0.004342194,0.001473391,0.0008815243,0.0005105066,0.001092194,0.000620349,0.0008804133],"category_scores_gemma":[0.00296635,0.000853377,0.001391871,0.003727204,0.001220851,0.0001730385,0.001091156,0.005937072,0.001352927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001099937,"about_ca_system_score_gemma":0.002867094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001936365,"about_ca_topic_score_gemma":0.0001378808,"domain_scores_codex":[0.9863763,0.00286359,0.003549343,0.002952978,0.002169886,0.002087938],"domain_scores_gemma":[0.9862772,0.00835534,0.0005841034,0.00185523,0.001504918,0.001423175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007296887,0.001062965,0.001149934,0.04275047,0.001073754,0.0004647589,0.00002667703,8.470873e-7,0.000003572158,0.0004091112,0.5926109,0.3597173],"study_design_scores_gemma":[0.00282047,0.002573802,0.003915608,0.02180135,0.001726447,0.0009899252,0.00001759848,0.000199053,0.000001063564,0.0002975827,0.96479,0.0008670409],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0026808,0.9718756,0.000008924902,0.009880034,0.001274118,0.00882392,0.004585505,0.0004112955,0.0004597812],"genre_scores_gemma":[0.002451683,0.9849612,0.0004221172,0.0009812373,0.001611809,0.005533538,0.001797512,0.0004906053,0.001750365],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.3721792,"threshold_uncertainty_score":0.9994246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4323668482449535,"score_gpt":0.539893201562797,"score_spread":0.1075263533178434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}