{"id":"W4404382271","doi":"10.1016/j.freeradbiomed.2024.10.033","title":"Baseline Oxygen Level Affects the Transcriptional and Metabolic Responses of Prostate Cancer Cells to Hypoxia","year":2024,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Brock University","funders":"","keywords":"Hypoxia (environmental); Prostate cancer; Baseline (sea); Oxygen; Oncology; Internal medicine; Cancer; Biology; Medicine; Physiology; Cancer research; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009809632,0.00009623134,0.0003088426,0.0001265139,0.0001889242,0.0004232305,0.0001350168,0.0001788497,0.002028241],"category_scores_gemma":[0.0001580436,0.0001196659,0.000188296,0.0002234562,0.0002113015,0.0001719394,0.0001649592,0.0004162778,0.0001800841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002890035,"about_ca_system_score_gemma":0.0002683447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002291177,"about_ca_topic_score_gemma":0.002724343,"domain_scores_codex":[0.9998741,0.00001909724,0.00000569551,0.00002232842,0.00002751629,0.00005121185],"domain_scores_gemma":[0.9999079,0.00001729384,0.00001213701,0.00001191257,0.00001431419,0.00003649494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006271787,0.00006580776,0.001227326,0.00002025556,0.000006910482,0.00002563342,0.00004094944,0.00008627314,0.996662,0.0001038162,0.00009456204,0.001039288],"study_design_scores_gemma":[0.00005266632,0.001601259,0.1528292,0.00001003953,0.00004849333,0.0002046257,0.0005858431,0.001910796,0.8385436,0.0001943114,0.003995645,0.00002361781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971811,0.0008547266,0.0004728063,0.0001686583,0.00003175458,0.000007214466,0.0004113809,0.00002719213,0.0008453083],"genre_scores_gemma":[0.9980482,0.0002830183,0.0001359258,0.00005546842,0.000009330334,0.0000105782,0.0004164588,0.000005781,0.001035286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002291177,"threshold_uncertainty_score":0.006785095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01867566660050223,"score_gpt":0.293090694371673,"score_spread":0.2744150277711708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}