{"id":"W4404384004","doi":"10.1039/d4fo03322a","title":"Cross-domain binding of anti-fibrillation peptide TNGQ to islet amyloid polypeptide provides cytoprotective effects in giant unilamellar vesicles and pancreatic β-cells","year":2024,"lang":"en","type":"article","venue":"Food & Function","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; University of Ottawa","keywords":"Islet; Amyloid (mycology); Cytotoxicity; Fibrillation; Peptide; Vesicle; Chemistry; Fibril; Pancreatic islets; Cell biology; Biochemistry; Pancreatic polypeptide; Biophysics; Insulin; Internal medicine; In vitro; Biology; Endocrinology; Membrane; Medicine; Atrial fibrillation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001030058,0.0003084004,0.0001888138,0.00008257839,0.00005756666,0.000119605,0.000139803,0.0002490036,0.0004378621],"category_scores_gemma":[0.00008925209,0.00008800131,0.0002262926,0.00008183945,0.000107945,0.0001058662,0.0001287646,0.0003129468,0.0001342952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001267497,"about_ca_system_score_gemma":0.0000725724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003784214,"about_ca_topic_score_gemma":0.0002563557,"domain_scores_codex":[0.9999305,0.0000165296,0.000007810383,0.00001492047,0.00001282836,0.00001732413],"domain_scores_gemma":[0.9999453,0.000009004724,0.00001834035,0.000005481721,0.000007559597,0.00001439061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006411326,0.00001083183,0.00005981224,0.00001121802,0.000002474143,0.00002458393,0.000003975368,0.0000164299,0.9994968,0.000009566244,0.000005112346,0.0002950118],"study_design_scores_gemma":[0.00001882973,0.0006947528,0.003521331,0.000003250076,0.00001242264,0.0002480371,0.00001031976,0.0004249079,0.9945931,0.00001153552,0.0004595349,0.000001971263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982102,0.0007376325,0.0006984358,0.00001918919,0.00000969051,0.000009155002,0.00004353829,0.00001501606,0.0002573142],"genre_scores_gemma":[0.9982982,0.0004086126,0.0006597501,0.00004388837,0.000004078981,0.00001074157,0.0001566737,0.000006423292,0.0004115946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004378621,"threshold_uncertainty_score":0.001464784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01359321996830645,"score_gpt":0.2767941628473582,"score_spread":0.2632009428790518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}