{"id":"W4404384004","doi":"10.1039/d4fo03322a","title":"Cross-domain binding of anti-fibrillation peptide TNGQ to islet amyloid polypeptide provides cytoprotective effects in giant unilamellar vesicles and pancreatic β-cells","year":2024,"lang":"en","type":"article","venue":"Food & Function","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; University of Ottawa","keywords":"Islet; Amyloid (mycology); Cytotoxicity; Fibrillation; Peptide; Vesicle; Chemistry; Fibril; Pancreatic islets; Cell biology; Biochemistry; Pancreatic polypeptide; Biophysics; Insulin; Internal medicine; In vitro; Biology; Endocrinology; Membrane; Medicine; Atrial fibrillation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002371463,0.0001916676,0.0003180879,0.0004097584,0.00007918111,0.00006740642,0.00003083722,0.00007065666,0.00001775593],"category_scores_gemma":[0.00009559825,0.0001616868,0.00008071528,0.0004703019,0.00007474278,0.0002069329,0.000041807,0.000141204,0.000060406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001750436,"about_ca_system_score_gemma":0.0001320075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002048542,"about_ca_topic_score_gemma":0.00002630778,"domain_scores_codex":[0.9986144,0.0001008075,0.0002531724,0.0003979181,0.0003274002,0.0003063324],"domain_scores_gemma":[0.999334,0.0001741533,0.00005378016,0.0001856988,0.00006696487,0.0001853369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005224023,0.000182947,0.08155958,0.001583052,0.002488851,0.0001785588,0.0006167875,0.0001031147,0.899277,0.0003557957,0.00003770998,0.008392604],"study_design_scores_gemma":[0.002840315,0.01911758,0.5993124,0.002373233,0.0006846619,0.00004450235,0.0003976645,0.0008699525,0.3724868,0.001289143,0.000272369,0.0003113583],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935454,0.003857014,0.0005207377,0.0001047784,0.0001087581,0.001549706,0.00003624251,0.00006510845,0.0002122404],"genre_scores_gemma":[0.9991855,0.00008078798,0.0004013864,0.00002196701,0.0001329393,0.00006651253,0.00004029337,0.00003556994,0.00003502874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5267901,"threshold_uncertainty_score":0.6593394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01359321996830645,"score_gpt":0.2767941628473582,"score_spread":0.2632009428790518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}