{"id":"W4404387688","doi":"10.1080/17576180.2024.2411925","title":"Harmonization of Vaccine Ligand Binding Assays Validation","year":2024,"lang":"en","type":"article","venue":"Bioanalysis","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Health Canada; Ministry of Health, Labour and Welfare; U.S. Food and Drug Administration; Sanofi","keywords":"Harmonization; Computational biology; Chemistry; Biochemical engineering; Virology; Chromatography; Biology; Engineering; Physics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.2776084,0.002331658,0.00312017,0.01088039,0.002670136,0.0110795,0.007074425,0.004257719,0.0058159],"category_scores_gemma":[0.1522791,0.001606765,0.003299247,0.004188053,0.005040883,0.004993781,0.009909997,0.006218802,0.007506612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004523218,"about_ca_system_score_gemma":0.01781113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003828128,"about_ca_topic_score_gemma":0.003585045,"domain_scores_codex":[0.7717858,0.1147947,0.01685181,0.0150915,0.07550015,0.005975965],"domain_scores_gemma":[0.8067895,0.04700592,0.00818448,0.04484136,0.09090427,0.002274432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001364011,0.0009571481,0.02401671,0.008390678,0.0007977254,0.0007244507,0.007021739,0.0116157,0.1543602,0.0550889,0.1119805,0.6236821],"study_design_scores_gemma":[0.0001562123,0.001280562,0.02013468,0.0036866,0.0004446227,0.0008857764,0.00227248,0.01462405,0.1690056,0.02413151,0.7630423,0.0003356678],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.05189491,0.02215496,0.7894243,0.02026594,0.007443524,0.01032349,0.008590044,0.009949418,0.07995343],"genre_scores_gemma":[0.2900308,0.01141745,0.5996211,0.02161205,0.001633069,0.01247954,0.02803354,0.005198392,0.02997393],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.2776084,"threshold_uncertainty_score":0.8908375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02231898698219726,"score_gpt":0.2931837167912041,"score_spread":0.2708647298090069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}