{"id":"W4404393343","doi":"10.21203/rs.3.rs-4746517/v1","title":"Trial protocol for Siroskin: a randomised double-blind placebo-controlled trial of topical sirolimus in chemoprevention of facial squamous cell carcinomas in solid organ transplant recipients","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Nonmelanoma Skin Cancer Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"SKiN Health","funders":"","keywords":"Medicine; Sirolimus; Solid organ; Placebo; Clinical trial; Double blind; Organ transplantation; Protocol (science); Randomized controlled trial; Internal medicine; Transplantation; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004342287,0.0005248541,0.002967758,0.001404126,0.00006564042,0.00003916687,0.0004325664,0.0008588296,0.0001001294],"category_scores_gemma":[0.0009189961,0.0004386431,0.001028098,0.0006322666,0.0002710117,0.0000388551,0.0005060185,0.002036863,0.00000423569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009032158,"about_ca_system_score_gemma":0.002187598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004962549,"about_ca_topic_score_gemma":0.000668946,"domain_scores_codex":[0.9929726,0.0008796933,0.002408818,0.001064521,0.001788184,0.0008862183],"domain_scores_gemma":[0.9966782,0.001431806,0.0004804629,0.0007163642,0.000501314,0.0001918902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9754294,0.003516419,0.001816103,0.01357091,0.0002120449,0.000133245,0.003271353,0.00006010746,0.001397603,0.00002385348,0.00008454602,0.000484379],"study_design_scores_gemma":[0.9710993,0.007619687,0.001136802,0.003142783,0.0002210283,0.0000035265,0.0002161298,0.0003702177,0.01508573,0.0007293536,0.00008221919,0.0002932043],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5905673,0.00007551001,0.00002507316,0.0001652521,0.0004297359,0.4075522,0.0001137365,0.00001596941,0.001055253],"genre_scores_gemma":[0.5956007,0.00001346179,0.00007386947,0.000001775794,0.0006526294,0.4030356,0.00006990808,0.00005264546,0.0004993942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01368812,"threshold_uncertainty_score":0.9998065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1091695655151607,"score_gpt":0.4459869206522754,"score_spread":0.3368173551371146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}