{"id":"W4404393343","doi":"10.21203/rs.3.rs-4746517/v1","title":"Trial protocol for Siroskin: a randomised double-blind placebo-controlled trial of topical sirolimus in chemoprevention of facial squamous cell carcinomas in solid organ transplant recipients","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Nonmelanoma Skin Cancer Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"SKiN Health","funders":"","keywords":"Medicine; Sirolimus; Solid organ; Placebo; Clinical trial; Double blind; Organ transplantation; Protocol (science); Randomized controlled trial; Internal medicine; Transplantation; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01513669,0.005726474,0.006426714,0.001421816,0.002270449,0.003049757,0.002294606,0.007389878,0.1010458],"category_scores_gemma":[0.01699248,0.002408704,0.004357994,0.001256542,0.003197237,0.002202726,0.001356839,0.00806119,0.02159707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002381044,"about_ca_system_score_gemma":0.005889876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001633535,"about_ca_topic_score_gemma":0.00278518,"domain_scores_codex":[0.9903402,0.005034844,0.001110949,0.00174625,0.0007359256,0.001031878],"domain_scores_gemma":[0.9941294,0.001644767,0.001200876,0.00108118,0.000804743,0.00113903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9600697,0.001552901,0.0001993521,0.00514896,0.001072074,0.00008751776,0.00008939398,0.0003517923,0.001410787,0.002663483,0.01559972,0.01175441],"study_design_scores_gemma":[0.9722753,0.004929984,0.0004008977,0.0005157724,0.000404919,0.00002732567,0.00001657961,0.0004969489,0.0003035934,0.000992752,0.01960212,0.00003386799],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.009926744,0.001972929,0.006511185,0.001655829,0.005444313,0.9584671,0.008250368,0.0008574767,0.00691417],"genre_scores_gemma":[0.01726296,0.0007554468,0.006862068,0.00220113,0.001018256,0.9618795,0.001687805,0.00009733271,0.00823548],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.1010458,"threshold_uncertainty_score":0.338032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1091695655151607,"score_gpt":0.4459869206522754,"score_spread":0.3368173551371146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}