{"id":"W4404395566","doi":"10.1158/1078-0432.ccr-24-2983","title":"Divergent Clinical and Immunologic Outcomes Based on STK11 Co-mutation Status in Resectable KRAS- Mutant Lung Cancers Following Neoadjuvant Immune Checkpoint Blockade","year":2024,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; McGill University; McGill University Health Centre","funders":"Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University; Swim Across America; American Lung Association; Mark Foundation For Cancer Research; Bristol-Myers Squibb; LUNGevity Foundation; National Cancer Institute; National Institutes of Health; Conquer Cancer Foundation","keywords":"KRAS; Immune checkpoint; Medicine; Lung cancer; Cancer research; Oncology; Context (archaeology); Cancer; Immunotherapy; Neoadjuvant therapy; Internal medicine; STK11; Biology; Colorectal cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001730143,0.0001455359,0.0002396716,0.0001911466,0.0001214877,0.0002855669,0.00009457004,0.0001854988,0.0008132069],"category_scores_gemma":[0.0002104885,0.00007559681,0.0001507398,0.0001436744,0.0002526358,0.0001498874,0.0001548106,0.0003319204,0.0001648852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002168362,"about_ca_system_score_gemma":0.0001304568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001816802,"about_ca_topic_score_gemma":0.0004236329,"domain_scores_codex":[0.9998574,0.00002096362,0.00001340358,0.00003763472,0.00003287954,0.00003766071],"domain_scores_gemma":[0.9998154,0.00002875165,0.00006914088,0.00001167872,0.00001663558,0.00005843417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006644625,0.0003390557,0.1472562,0.00007862447,0.00005754473,0.0003333145,0.0001292728,0.0003758327,0.8349363,0.00004981582,0.0001723645,0.00962694],"study_design_scores_gemma":[0.00006745351,0.005324183,0.8857082,0.00001036641,0.0001034184,0.001565842,0.0003226752,0.001318238,0.1046528,0.00008194687,0.0008308678,0.00001402148],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995436,0.00009298537,0.00006823397,0.00001071404,0.000002702249,0.000008934222,0.00008363756,0.000003673138,0.0001854096],"genre_scores_gemma":[0.9995013,0.00004784613,0.00006362669,0.00001791152,0.000002436986,0.00001465422,0.0002142077,0.000001816089,0.0001361396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008132069,"threshold_uncertainty_score":0.002720475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1293539012176479,"score_gpt":0.506675577321772,"score_spread":0.3773216761041241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}