{"id":"W4404402853","doi":"10.1016/j.jinf.2024.106346","title":"The Platform Trial In COVID-19 priming and BOOsting (PICOBOO): The immunogenicity, reactogenicity, and safety of licensed COVID-19 vaccinations administered as a second booster in BNT162b2 primed individuals aged 18-&lt;50 and 50-&lt;70 years old","year":2024,"lang":"en","type":"article","venue":"Journal of Infection","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Snow Foundation; National Health and Medical Research Council; Children’s Hospital of Wisconsin Research Institute; Snow Medical; Institute of Infection and Immunity; Doherty Institute; National Institute for Health and Care Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Reactogenicity; Immunogenicity; Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Booster (rocketry); Medicine; Boosting (machine learning); Vaccination; Virology; Booster dose; Immunology; Computer science; Immune system; Internal medicine; Infectious disease (medical specialty); Engineering; Outbreak; Artificial intelligence; Immunization","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00527627,0.0002142267,0.0005001248,0.0007679705,0.0002822921,0.0002843567,0.0001349754,0.000221642,0.00002704333],"category_scores_gemma":[0.005020833,0.0001475054,0.0001442336,0.0005329177,0.0001661539,0.0004331956,0.0002048785,0.0009823273,0.000001336413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000566498,"about_ca_system_score_gemma":0.001404903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006810863,"about_ca_topic_score_gemma":0.001992984,"domain_scores_codex":[0.9973409,0.0003649413,0.001117595,0.0002831198,0.0005613752,0.0003320236],"domain_scores_gemma":[0.9958819,0.003111337,0.0004968372,0.0002303764,0.0001201218,0.0001594155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.07002018,0.000880414,0.5424251,0.002352494,0.001574563,0.0006252069,0.04105103,0.00001945734,0.2998594,0.0007045647,0.001130121,0.03935744],"study_design_scores_gemma":[0.1069442,0.005336026,0.7361661,0.001732414,0.0007101789,0.005924067,0.003234985,0.0005940686,0.02512711,0.002990443,0.1105878,0.0006525176],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938449,0.002478854,0.00007946474,0.001774969,0.0002642028,0.001240516,0.00001206275,0.00002095901,0.0002840553],"genre_scores_gemma":[0.9944235,0.000563941,0.00003951199,0.004678415,0.0002044307,0.00002724392,0.000002829715,0.00002649498,0.00003364156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2747323,"threshold_uncertainty_score":0.6015096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06749618561803421,"score_gpt":0.3814259091922689,"score_spread":0.3139297235742347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}