{"id":"W4404402853","doi":"10.1016/j.jinf.2024.106346","title":"The Platform Trial In COVID-19 priming and BOOsting (PICOBOO): The immunogenicity, reactogenicity, and safety of licensed COVID-19 vaccinations administered as a second booster in BNT162b2 primed individuals aged 18-<50 and 50-<70 years old","year":2024,"lang":"en","type":"article","venue":"Journal of Infection","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Snow Foundation; National Health and Medical Research Council; Children’s Hospital of Wisconsin Research Institute; Snow Medical; Institute of Infection and Immunity; Doherty Institute; National Institute for Health and Care Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Reactogenicity; Immunogenicity; Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Booster (rocketry); Medicine; Boosting (machine learning); Vaccination; Virology; Booster dose; Immunology; Computer science; Immune system; Internal medicine; Infectious disease (medical specialty); Engineering; Outbreak; Artificial intelligence; Immunization","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0037981,0.00103011,0.001084548,0.0001828838,0.0003817536,0.0007256044,0.0005960765,0.00105886,0.002390691],"category_scores_gemma":[0.003422872,0.0004057666,0.0006539436,0.0001796891,0.0008469042,0.0007483046,0.001103996,0.002200375,0.0003637887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006126261,"about_ca_system_score_gemma":0.001413455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009379467,"about_ca_topic_score_gemma":0.001234286,"domain_scores_codex":[0.9986193,0.000891111,0.0000372892,0.0001846146,0.00009725842,0.0001704874],"domain_scores_gemma":[0.9978786,0.0005996788,0.0005166092,0.0002413016,0.0001193171,0.0006445989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9459296,0.007837313,0.01090337,0.0003472795,0.0003951791,0.00006006486,0.0002957881,0.0007617501,0.005897678,0.0005143927,0.0009043419,0.02615333],"study_design_scores_gemma":[0.2822401,0.6812289,0.02631056,0.0001497747,0.000559828,0.0001399218,0.0001279957,0.001730273,0.003463064,0.0007008496,0.003297979,0.00005086854],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963631,0.0005515941,0.0004011048,0.0001471179,0.0001236466,0.001141052,0.0002396998,0.00001937715,0.001013229],"genre_scores_gemma":[0.9935999,0.0002759712,0.001409692,0.0003652327,0.0001693639,0.001988825,0.0005579447,0.0000138552,0.001619315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0037981,"threshold_uncertainty_score":0.02008653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06749618561803421,"score_gpt":0.3814259091922689,"score_spread":0.3139297235742347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}