{"id":"W4404405189","doi":"10.1021/acsnanoscienceau.4c00040","title":"Nanoparticles Codelivering mRNA and SiRNA for Simultaneous Restoration and Silencing of Gene/Protein Expression In Vitro and In Vivo","year":2024,"lang":"en","type":"article","venue":"ACS Nanoscience Au","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; National Research Council Canada; Ottawa Hospital; University of Ottawa","funders":"National Research Council Canada; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Research, Innovation and Science","keywords":"Gene silencing; Messenger RNA; RNA interference; In vivo; Small interfering RNA; Gene expression; In vitro; Luciferase; microRNA; RNA; Cell biology; Gene; Biology; Molecular biology; Chemistry; Transfection; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001777713,0.00007067366,0.00008217934,0.00006685485,0.00004083569,0.00003091455,0.00005626951,0.00005716896,3.287901e-7],"category_scores_gemma":[0.0001136763,0.00006424558,0.000009546364,0.00008359772,0.00009054131,0.00002252592,0.00006064674,0.0000319117,9.812045e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001301881,"about_ca_system_score_gemma":0.00004354721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009800649,"about_ca_topic_score_gemma":0.0001563354,"domain_scores_codex":[0.9993746,0.00001726542,0.0001421623,0.0002684178,0.00006081177,0.0001367278],"domain_scores_gemma":[0.9998084,0.00003397405,0.0000273937,0.00007691016,0.00002295664,0.00003040115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008468155,0.000008499017,0.0005237467,0.00004376121,0.000001150122,0.000004909441,0.0003895145,0.0001652011,0.9930409,0.000004003738,0.000003662015,0.005730007],"study_design_scores_gemma":[0.0001697373,0.0001613985,0.0003302063,0.0001105661,0.000002293947,0.000006633601,0.0002356889,0.01373605,0.9850609,0.00005768981,0.00005321919,0.00007565408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975635,0.001698693,0.0004860911,0.00003528459,0.00003996982,0.0001551966,0.00001023737,0.000003367938,0.00000768333],"genre_scores_gemma":[0.998677,0.0002387184,0.0009906146,0.00002225816,0.00001876295,0.0000151008,0.000002104474,0.000004869976,0.0000306371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01357085,"threshold_uncertainty_score":0.2619859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01164899769166827,"score_gpt":0.2501474703071365,"score_spread":0.2384984726154682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}