{"id":"W4404405189","doi":"10.1021/acsnanoscienceau.4c00040","title":"Nanoparticles Codelivering mRNA and SiRNA for Simultaneous Restoration and Silencing of Gene/Protein Expression In Vitro and In Vivo","year":2024,"lang":"en","type":"article","venue":"ACS Nanoscience Au","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; National Research Council Canada; Ottawa Hospital; University of Ottawa","funders":"National Research Council Canada; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Research, Innovation and Science","keywords":"Gene silencing; Messenger RNA; RNA interference; In vivo; Small interfering RNA; Gene expression; In vitro; Luciferase; microRNA; RNA; Cell biology; Gene; Biology; Molecular biology; Chemistry; Transfection; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016164,0.000292403,0.0001862448,0.0001582095,0.0001455969,0.0001904026,0.0001786632,0.0003357172,0.0005627978],"category_scores_gemma":[0.0001449545,0.0001483282,0.0001854429,0.00009886477,0.0002164068,0.0001744718,0.0001442231,0.0003394228,0.0002544755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000360466,"about_ca_system_score_gemma":0.0003088821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007338312,"about_ca_topic_score_gemma":0.0015131,"domain_scores_codex":[0.999884,0.00001447353,0.000009295287,0.00003352642,0.00004395985,0.00001471794],"domain_scores_gemma":[0.9999392,0.00001295701,0.00001767507,0.000005628104,0.00001586824,0.000008679897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001234747,0.00000853704,0.00002091093,0.00002583225,0.000001665105,0.00002032454,0.000008562195,0.00007305187,0.9979572,0.0002135779,0.0000633548,0.00159466],"study_design_scores_gemma":[0.000003740944,0.00006669128,0.0001201689,0.000001631161,0.000005189716,0.00005829846,0.000003233759,0.0009219724,0.9970093,0.00002596247,0.001781572,0.000002249492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8590273,0.004529804,0.123371,0.0004322053,0.0002677987,0.0002296743,0.0002961748,0.0007744564,0.01107157],"genre_scores_gemma":[0.9502667,0.001534179,0.0394017,0.0001893738,0.00002450711,0.0001583528,0.000269155,0.00007275982,0.008083291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007338312,"threshold_uncertainty_score":0.002615333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01164899769166827,"score_gpt":0.2501474703071365,"score_spread":0.2384984726154682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}