{"id":"W4404405312","doi":"10.48550/arxiv.2411.07258","title":"A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new $β$-arrestin inhibitor","year":2024,"lang":"en","type":"preprint","venue":"arXiv (Cornell University)","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Région Normandie; Réseau québécois de recherche sur la douleur; Canadian Institutes of Health Research; European Commission; Université de Sherbrooke","keywords":"Terminal (telecommunication); Receptor; Peptide; Chemistry; Cell biology; Internal medicine; Endocrinology; Computer science; Biology; Biochemistry; Medicine; Telecommunications","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001010459,0.0003666925,0.0003592251,0.0001275105,0.0001026545,0.0002512984,0.0002183366,0.0003241307,0.0006341789],"category_scores_gemma":[0.0000798698,0.0001039295,0.0002561947,0.0001064967,0.0001292143,0.000227266,0.0001297215,0.000724184,0.0003521232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002123479,"about_ca_system_score_gemma":0.0001102458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001928004,"about_ca_topic_score_gemma":0.0003933125,"domain_scores_codex":[0.9999297,0.00000837316,0.000005744683,0.00002053853,0.00002207945,0.00001362201],"domain_scores_gemma":[0.9999652,0.000006573863,0.00001119469,0.000002882437,0.000004935457,0.000009287633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006201891,0.00001927934,0.00003633845,0.00005406575,0.000006865565,0.00005177473,0.00000665865,0.0001426144,0.9970672,0.0001263036,0.00006820195,0.002358586],"study_design_scores_gemma":[0.00004448821,0.0007509326,0.0008682514,0.000008750411,0.00002512129,0.0004099754,0.00001065732,0.001287025,0.9873268,0.0000513779,0.009202897,0.00001372088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9627879,0.01425836,0.01650059,0.0004589472,0.0001645599,0.00016196,0.000743886,0.0002877672,0.004636039],"genre_scores_gemma":[0.976091,0.007777185,0.01034452,0.0002429125,0.00004737257,0.0001169784,0.0008965377,0.00004259486,0.004440811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006341789,"threshold_uncertainty_score":0.002121568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03479421421752468,"score_gpt":0.1912179056809754,"score_spread":0.1564236914634507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}