{"id":"W4404408437","doi":"10.1101/2024.11.13.623500","title":"Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroendocrine Tumor Research Advances","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Tuft; Lineage (genetic); Basal (medicine); Biology; Cell lineage; Evolutionary biology; Genetics; Cellular differentiation; Gene; Endocrinology; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0002286646,0.000816609,0.001346317,0.001084976,0.00005384656,0.000104194,0.0006643673,0.00008256586,0.0001707449],"category_scores_gemma":[0.0007692941,0.0008030582,0.0002964273,0.001203366,0.0003071325,0.0001207005,0.001439542,0.00302688,0.00008606205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004333017,"about_ca_system_score_gemma":0.001973379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005667584,"about_ca_topic_score_gemma":0.00005403087,"domain_scores_codex":[0.9948995,0.0002029332,0.001112004,0.001610516,0.001025941,0.001149079],"domain_scores_gemma":[0.9970577,0.0002350561,0.0003935733,0.001270975,0.0004880597,0.000554677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006298267,0.0008634201,0.05716212,0.01036331,0.0001332755,0.01934683,0.000009302458,0.0005008412,0.9079539,0.0002298705,0.002804984,0.000002321948],"study_design_scores_gemma":[0.001730749,0.0003706467,0.05969469,0.002554526,0.0002421365,5.510136e-7,0.000004560206,0.001261846,0.9237549,0.000006435448,0.009662599,0.0007163658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909468,0.004060263,0.00002653995,0.0008799563,0.0016581,0.001494001,0.000512757,0.0003526825,0.00006888384],"genre_scores_gemma":[0.9945974,0.002000598,0.001665054,0.0002277757,0.0006940968,0.0004159403,5.129519e-7,0.0002829305,0.0001156631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01934628,"threshold_uncertainty_score":0.999442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02558297377629473,"score_gpt":0.3012596008500769,"score_spread":0.2756766270737822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}