{"id":"W4404417581","doi":"10.21203/rs.3.rs-5289961/v1","title":"Disease Remission and Sustained Remission After Etanercept Biosimilar or Originator Initiation in Rheumatoid Arthritis: An Interim Real-World Analysis","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; Canadian Arthritis Patient Alliance; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; McGill University; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Centre Hospitalier Universitaire de Sherbrooke; McGill University Health Centre","funders":"","keywords":"Biosimilar; Etanercept; Rheumatoid arthritis; Medicine; Interim; Interim analysis; Internal medicine; Disease; Immunology; Clinical trial; Political science; Law","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01444943,0.0008144908,0.002127466,0.001116623,0.0005744954,0.00307663,0.001048496,0.00199455,0.004569982],"category_scores_gemma":[0.01854425,0.0004983651,0.003182571,0.001358129,0.001286282,0.001914975,0.001362361,0.002270459,0.0009852435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001087048,"about_ca_system_score_gemma":0.0009289764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001751931,"about_ca_topic_score_gemma":0.001094521,"domain_scores_codex":[0.9912528,0.004316201,0.0006400234,0.001229439,0.001346548,0.001214996],"domain_scores_gemma":[0.9809065,0.01001691,0.004011719,0.002672228,0.001350447,0.001042077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.3763168,0.002991595,0.5341947,0.001048957,0.006206235,0.001061835,0.0009540506,0.005743393,0.005851273,0.0009495909,0.003093991,0.06158754],"study_design_scores_gemma":[0.003591978,0.02606223,0.945451,0.0001266776,0.00675642,0.001100569,0.0007465413,0.005276189,0.004453612,0.001118533,0.005135111,0.000181137],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898512,0.001560452,0.00159177,0.0001717632,0.0000535962,0.0001534173,0.004857686,0.00004712389,0.001712982],"genre_scores_gemma":[0.9928102,0.0002321696,0.0007383995,0.00009785698,0.00005429447,0.0001073504,0.00500288,0.00002114786,0.0009356334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01444943,"threshold_uncertainty_score":0.07641679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.058991147044761,"score_gpt":0.4302678272406184,"score_spread":0.3712766801958574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}