{"id":"W4404419027","doi":"10.3390/molecules29225382","title":"Unveiling the Anticancer Potential of a New Ciprofloxacin-Chalcone Hybrid as an Inhibitor of Topoisomerases I & II and Apoptotic Inducer","year":2024,"lang":"en","type":"article","venue":"Molecules","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"King Khalid University","keywords":"Chalcone; Topoisomerase; Inducer; Apoptosis; Ciprofloxacin; Chemistry; Pharmacology; Topoisomerase inhibitor; Topotecan; Stereochemistry; Biology; Biochemistry; DNA; Antibiotics; Chemotherapy; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001004267,0.0001298469,0.0001521988,0.00004486157,0.00005685682,0.00002486153,0.0001116768,0.00006330444,0.00004403762],"category_scores_gemma":[0.00001526819,0.0000990362,0.00007712501,0.00007658934,0.0001019016,0.000005285894,0.0001113995,0.00007371591,0.000001928945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006013242,"about_ca_system_score_gemma":0.0001389293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000134627,"about_ca_topic_score_gemma":0.00003382114,"domain_scores_codex":[0.999224,0.00002806748,0.0001946018,0.000269327,0.0001320665,0.0001519235],"domain_scores_gemma":[0.9995669,0.000007549614,0.00005387968,0.0002566701,0.00005036551,0.00006470918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006649503,0.00003680254,0.00000761091,0.00004824046,0.00009306667,0.000003060771,0.0002129596,0.00002935446,0.9868869,0.001216002,0.0001622916,0.01123719],"study_design_scores_gemma":[0.0002680967,0.0004252098,0.00006110229,0.00005700496,0.00007216618,0.00002065078,0.0001247472,0.0001271819,0.9864944,0.001451575,0.0107747,0.0001231941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883042,0.007740496,0.003055614,0.0003404189,0.0002470241,0.0001447902,0.0000390092,0.000009418772,0.0001190109],"genre_scores_gemma":[0.9978928,0.0006107861,0.000419327,0.0002184141,0.0002585569,0.000007166492,0.00003430331,0.00002433465,0.0005343193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.011114,"threshold_uncertainty_score":0.4038579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01442007551283325,"score_gpt":0.2787396768344386,"score_spread":0.2643196013216054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}