{"id":"W4404419027","doi":"10.3390/molecules29225382","title":"Unveiling the Anticancer Potential of a New Ciprofloxacin-Chalcone Hybrid as an Inhibitor of Topoisomerases I & II and Apoptotic Inducer","year":2024,"lang":"en","type":"article","venue":"Molecules","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"King Khalid University","keywords":"Chalcone; Topoisomerase; Inducer; Apoptosis; Ciprofloxacin; Chemistry; Pharmacology; Topoisomerase inhibitor; Topotecan; Stereochemistry; Biology; Biochemistry; DNA; Antibiotics; Chemotherapy; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007177699,0.0002078399,0.0001774415,0.0002432074,0.0001016655,0.000213466,0.0001659024,0.0002179163,0.0009915181],"category_scores_gemma":[0.00007006493,0.00006031721,0.0001152978,0.0001446723,0.0001170733,0.0001974672,0.0001002024,0.0002810559,0.0001487203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002338841,"about_ca_system_score_gemma":0.0001449803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006034775,"about_ca_topic_score_gemma":0.00143083,"domain_scores_codex":[0.9999617,0.000006984462,0.000002237072,0.000007146345,0.00001343722,0.000008451763],"domain_scores_gemma":[0.9999654,0.00000498087,0.000006580602,0.000002489835,0.000008933142,0.00001156425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001446328,0.00004894117,0.000245777,0.0001082308,0.000008163351,0.0001278057,0.0000108942,0.0003641943,0.9942268,0.0001352329,0.00004842558,0.004530872],"study_design_scores_gemma":[0.00005607173,0.00217699,0.003486873,0.00001443494,0.00003629282,0.0005055777,0.00004110159,0.002755693,0.9855897,0.00007612654,0.005246611,0.00001455809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885911,0.003792279,0.005290817,0.0001430626,0.00002408966,0.00007315207,0.0002215723,0.00005793653,0.00180599],"genre_scores_gemma":[0.993623,0.001266388,0.003647275,0.0000398145,0.000008123595,0.00001777778,0.0002028065,0.000004717044,0.00119016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009915181,"threshold_uncertainty_score":0.003316998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01442007551283325,"score_gpt":0.2787396768344386,"score_spread":0.2643196013216054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}