{"id":"W4404421305","doi":"10.1101/2024.11.14.623614","title":"TUDCA modulates drug bioavailability to regulate resistance to acute ER stress in <i>Saccharomyces cerevisiae</i>","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Bioavailability; Saccharomyces cerevisiae; Drug; Pharmacology; Chemistry; Medicine; Biochemistry; Yeast","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001283623,0.0002374971,0.000277788,0.0001179286,0.0001696109,0.0006026194,0.0003785809,0.0002406509,0.001516171],"category_scores_gemma":[0.0001369774,0.00012222,0.0001736469,0.0001575686,0.0002411189,0.0002105949,0.000220769,0.0004737807,0.0004193846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004873227,"about_ca_system_score_gemma":0.0001962478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001192106,"about_ca_topic_score_gemma":0.001224705,"domain_scores_codex":[0.9999032,0.00001455567,0.000014476,0.00002698223,0.00001676317,0.00002401063],"domain_scores_gemma":[0.9998829,0.00001818498,0.00003555922,0.00001368307,0.00001594886,0.00003366409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002550123,0.00003942013,0.0001320119,0.00002207883,0.000004904032,0.00001896433,0.00001055313,0.00005469385,0.9985797,0.00008432782,0.00006406054,0.000734228],"study_design_scores_gemma":[0.00002978527,0.0001639681,0.001897585,0.000004877462,0.00001226815,0.00002969737,0.00002307465,0.0009909766,0.9952667,0.00002661413,0.001549479,0.000005079715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953209,0.0008977818,0.001474962,0.0001498667,0.00002928311,0.00002333322,0.0006279899,0.0001615996,0.001314314],"genre_scores_gemma":[0.9967021,0.0003769432,0.0007405959,0.00006147427,0.000006895093,0.00001679921,0.0004648113,0.00005659454,0.001573664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001516171,"threshold_uncertainty_score":0.005072057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005031705995867166,"score_gpt":0.2075675166110383,"score_spread":0.2025358106151711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}