{"id":"W4404432045","doi":"10.1371/journal.ppat.1012118","title":"The T4bSS of Legionella features a two-step secretion pathway with an inner membrane intermediate for secretion of transmembrane effectors","year":2024,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovation Cluster (Canada)","funders":"National Institute of Allergy and Infectious Diseases; Medizinischen Fakultät, Eberhard Karls Universität Tübingen; H2020 European Research Council; Agence Nationale de la Recherche; Fondation pour la Recherche Médicale; Deutsche Forschungsgemeinschaft","keywords":"Effector; Secretion; Cell biology; Periplasmic space; Legionella pneumophila; Transmembrane protein; Biology; Cytoplasm; Inner membrane; Membrane protein; Transmembrane domain; Secretory protein; Transport protein; Biochemistry; Membrane; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003869842,0.0001852631,0.0002151403,0.00007898447,0.00009547552,0.00003510442,0.0002164117,0.0001436583,0.000004824878],"category_scores_gemma":[0.00005142494,0.0001141738,0.0001579484,0.0001794587,0.0002299682,0.00001022682,0.00003493126,0.0001367531,0.00000126019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001273786,"about_ca_system_score_gemma":0.0001261945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002466069,"about_ca_topic_score_gemma":0.0001455424,"domain_scores_codex":[0.9986997,0.0001383918,0.0002508685,0.0003636939,0.0002673517,0.0002799671],"domain_scores_gemma":[0.999197,0.0001043572,0.00007856372,0.0003453525,0.0001875665,0.00008718145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000901041,0.00008508681,0.0001970887,0.0005470999,0.0001624187,0.000007952599,0.0003043434,0.00006067996,0.9939748,0.000370305,0.0000737899,0.003315376],"study_design_scores_gemma":[0.0008878793,0.001690886,0.0004462904,0.0001856577,0.00008815234,0.00001988357,0.0002065749,0.002470157,0.9915573,0.00006578169,0.002201623,0.0001798428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956114,0.001051922,0.001977698,0.000151222,0.0001383627,0.0006517833,0.0002101419,0.00002096136,0.0001864729],"genre_scores_gemma":[0.9982597,0.0004183452,0.0001949349,0.00002217185,0.0002652578,0.0001066169,0.0004382397,0.00004560184,0.0002491424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003135533,"threshold_uncertainty_score":0.4655873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01118374302512349,"score_gpt":0.2581600333763551,"score_spread":0.2469762903512316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}