{"id":"W4404435982","doi":"10.1080/02652048.2024.2427294","title":"Development, QbD-based optimisation, <i>in-vivo</i> pharmacokinetics, and <i>ex-vivo</i> evaluation of Eudragit <sup>®</sup> RS 100 loaded flurbiprofen nanoparticles for oral drug delivery","year":2024,"lang":"en","type":"article","venue":"Journal of Microencapsulation","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Flurbiprofen; Ex vivo; Pharmacokinetics; In vivo; Drug delivery; Materials science; Pharmacology; Nanoparticle; Drug; Nanotechnology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003572361,0.0002806461,0.0004368987,0.0003996092,0.0001218594,0.00004705833,0.0001924166,0.0001860611,0.0003169906],"category_scores_gemma":[0.0001341354,0.0002483433,0.0001562718,0.00038382,0.0001084964,0.000566799,0.00003570748,0.0004278838,0.000007950372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004166066,"about_ca_system_score_gemma":0.0006304274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001821022,"about_ca_topic_score_gemma":0.00002109193,"domain_scores_codex":[0.9968668,0.0005942785,0.001362412,0.0003085531,0.0004951102,0.0003728018],"domain_scores_gemma":[0.9974821,0.0005800119,0.0006267406,0.0001099132,0.001039209,0.0001620191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006117453,0.0001734789,0.002650102,0.000217972,0.0002002375,0.000009257115,0.001953848,0.2930062,0.6740025,0.00001717232,0.004607629,0.02254987],"study_design_scores_gemma":[0.003823236,0.00009714197,0.0004756211,0.0002068051,0.0004424417,0.00003775442,0.0003394475,0.3726651,0.5922874,0.0001879493,0.02922,0.0002170969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914964,0.00500023,0.001212099,0.0004398637,0.000732924,0.0009577595,0.00008402351,0.000030574,0.0000460693],"genre_scores_gemma":[0.9932763,0.0001566691,0.005844324,0.000253289,0.0002548674,0.00003611227,0.00003776516,0.00003039495,0.0001102771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08171512,"threshold_uncertainty_score":0.9999969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09558256397200166,"score_gpt":0.3982901170772044,"score_spread":0.3027075531052027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}