{"id":"W4404436484","doi":"10.1038/s41467-024-54147-8","title":"Structure of a dimeric full-length ABC transporter","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; General Electric (Canada); University of Toronto","funders":"Scheme for Promotion of Academic and Research Collaboration; Hospital for Sick Children; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada","keywords":"ATP-binding cassette transporter; Computational biology; Transporter; Computer science; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006574504,0.000266212,0.0002406945,0.0002109556,0.0004529413,0.0004864647,0.0004448884,0.0006293341,0.002113346],"category_scores_gemma":[0.00018949,0.0002598215,0.0001917995,0.0002235809,0.0001942795,0.0004750451,0.0001417013,0.0006516367,0.0008130423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00072052,"about_ca_system_score_gemma":0.0003933893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001026834,"about_ca_topic_score_gemma":0.0008171884,"domain_scores_codex":[0.9999465,0.000007030453,0.000003193593,0.00001874119,0.00001630305,0.000008164713],"domain_scores_gemma":[0.99993,0.000008066243,0.0000169076,0.000006428541,0.00001952162,0.00001904745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004215924,0.0001254394,0.001888777,0.000230066,0.00004173387,0.0008536006,0.0001385573,0.002868967,0.9768617,0.003280578,0.003479931,0.009809131],"study_design_scores_gemma":[0.0003440221,0.00151586,0.05655664,0.0001321178,0.0001930579,0.008712827,0.0007246471,0.1302391,0.6945559,0.007596794,0.0991729,0.0002560747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778785,0.004960126,0.01024211,0.001130831,0.0001310166,0.00004146438,0.001115955,0.0003320522,0.004167924],"genre_scores_gemma":[0.9766384,0.001777034,0.01096152,0.0002250281,0.00003814735,0.00004111218,0.004122386,0.00005746914,0.006138832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002113346,"threshold_uncertainty_score":0.007069826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01094105554935788,"score_gpt":0.2923934691374936,"score_spread":0.2814524135881357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}