{"id":"W4404442573","doi":"10.1016/j.ijpharm.2024.124938","title":"Posaconazole nanocrystals dry powder inhalers for the local treatment of invasive pulmonary aspergillosis","year":2024,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Basic and Applied Basic Research Foundation of Guangdong Province; Medical Research Council; Natural Science Foundation of Guangdong Province","keywords":"Posaconazole; Aspergillosis; Dry-powder inhaler; Pulmonary aspergillosis; Medicine; Pharmacology; Chemistry; Antifungal; Immunology; Amphotericin B; Dermatology; Asthma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002090761,0.0001173937,0.0001988275,0.000231406,0.00003779497,0.00002723867,0.0001514468,0.00005603405,0.0002347373],"category_scores_gemma":[0.00004558992,0.00007055755,0.0003510602,0.00009342129,0.0001163242,0.0001200703,0.0000207578,0.0001310346,0.000009890745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002475001,"about_ca_system_score_gemma":0.000381254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004097789,"about_ca_topic_score_gemma":0.000001394408,"domain_scores_codex":[0.9988095,0.0000320895,0.0004882648,0.00009395356,0.0004651874,0.0001110714],"domain_scores_gemma":[0.9984837,0.0004378953,0.0001854825,0.00007397889,0.0007313454,0.00008766275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003138914,0.001477461,0.00635348,0.0003672422,0.008746269,0.002617279,0.002524529,0.004665941,0.5413507,0.001493844,0.003787015,0.4234774],"study_design_scores_gemma":[0.00289749,0.0005323486,0.0007215881,0.0004306912,0.0009038761,0.001259187,0.001261586,0.01993615,0.7311022,0.0001086034,0.2407087,0.0001376128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9353275,0.02891589,0.007693948,0.01650874,0.008063905,0.0008416848,0.0002468315,0.00003858556,0.002362869],"genre_scores_gemma":[0.9946059,0.002580665,0.0001987467,0.0009922327,0.0008270712,0.000006394151,0.00001011816,0.00001893995,0.0007599103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4233398,"threshold_uncertainty_score":0.2877253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0484619344325962,"score_gpt":0.3710639510192476,"score_spread":0.3226020165866514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}