{"id":"W4404451153","doi":"10.1158/1538-7445.tumbody-pr018","title":"Abstract PR018: Inflammation-induced mechanotransduction is necessary and sufficient to create pre-cancerous squamous lung metaplasias and necessary to drive progression to dysplasia","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Inflammation; Mechanotransduction; Medicine; Lung; Dysplasia; Pathology; Cancer research; Internal medicine; Biology; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001243581,0.0003487002,0.0002718232,0.0003520967,0.0003304787,0.0004131656,0.0002523046,0.0003488862,0.01982829],"category_scores_gemma":[0.0001362601,0.0001757536,0.0002585999,0.000263946,0.0003016191,0.0002291925,0.0003297381,0.0007916816,0.003820556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000424174,"about_ca_system_score_gemma":0.0004314892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005183331,"about_ca_topic_score_gemma":0.000639125,"domain_scores_codex":[0.9998403,0.00001178058,0.00001546397,0.00003913675,0.0000575171,0.00003569877],"domain_scores_gemma":[0.9998572,0.00001487292,0.00003490095,0.0000147581,0.00002225672,0.00005599977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001694782,0.00003432294,0.0003620588,0.00007290494,0.000003076232,0.0002748548,0.00001342376,0.0000248008,0.9941566,0.0002876295,0.0005732963,0.004027503],"study_design_scores_gemma":[0.00006122853,0.0006257925,0.01631096,0.00002468961,0.00002100229,0.002193229,0.0001052711,0.0007377422,0.9549859,0.0002693498,0.02465247,0.00001239689],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9621398,0.002510628,0.006277901,0.001179995,0.0005765163,0.0001611568,0.003874539,0.0009009421,0.02237851],"genre_scores_gemma":[0.932981,0.001233174,0.003124725,0.0001817762,0.0001057822,0.0001043869,0.003889183,0.0001500592,0.05822997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01982829,"threshold_uncertainty_score":0.06633222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04279189732606305,"score_gpt":0.4011355353077976,"score_spread":0.3583436379817346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}