{"id":"W4404458603","doi":"10.1002/anie.202418725","title":"Aptamer and DNAzyme Based Colorimetric Biosensors for Pathogen Detection","year":2024,"lang":"en","type":"review","venue":"Angewandte Chemie International Edition","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Aptamer; Deoxyribozyme; Biosensor; Nanotechnology; Computational biology; Biology; Molecular biology; DNA; Biochemistry; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007761228,0.00157311,0.001179868,0.00296456,0.0003216699,0.00101366,0.001201165,0.001551586,0.003780787],"category_scores_gemma":[0.0007008804,0.000637535,0.00070631,0.003263305,0.0004996855,0.001659043,0.0008016137,0.002417358,0.004195897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009043114,"about_ca_system_score_gemma":0.0009702237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009513829,"about_ca_topic_score_gemma":0.001686272,"domain_scores_codex":[0.9995757,0.00004802487,0.00002811088,0.00008238987,0.0002197904,0.00004597185],"domain_scores_gemma":[0.9997483,0.00008842305,0.00003718773,0.00001048743,0.00009239168,0.00002320983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005494148,0.0001540491,0.0001534655,0.01969149,0.0001094559,0.0003171884,0.00008969272,0.001012459,0.03733816,0.01176765,0.03647362,0.8928378],"study_design_scores_gemma":[0.000008632302,0.00009519311,0.0002683505,0.001002107,0.00004268687,0.0007016407,0.00003070676,0.000278846,0.008046613,0.001457282,0.9880383,0.00002967828],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000520389,0.9908494,0.002267015,0.000335415,0.0007893202,0.00002485839,0.00005389106,0.0000474004,0.005112397],"genre_scores_gemma":[0.002253507,0.9899898,0.00200885,0.0003550687,0.0001965612,0.0000375868,0.0001050152,0.000007237266,0.005046422],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003780787,"threshold_uncertainty_score":0.01264799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02660375838350246,"score_gpt":0.334447740252364,"score_spread":0.3078439818688615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}