{"id":"W4404469914","doi":"10.1073/pnas.2407835121","title":"HIV-1 budding requires cortical actin disassembly by the oxidoreductase MICAL1","year":2024,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Université de Strasbourg; Centre National de la Recherche Scientifique; Institut Pasteur; Institute of Genetics; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Agence Nationale de Recherches sur le Sida et les Hépatites Virales; Sidaction","keywords":"Budding; Cell biology; Actin; Biology; Viral envelope; Endosome; Actin remodeling; Actin cytoskeleton; Cytoskeleton; Virology; Cell; Biochemistry; Human immunodeficiency virus (HIV)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001034627,0.0002909096,0.0001854275,0.0001574412,0.0002737172,0.0005187737,0.0002249564,0.0002628884,0.0005224518],"category_scores_gemma":[0.0001202515,0.0002528833,0.0002492468,0.00009870849,0.0001993608,0.0002507872,0.0004104113,0.0005010613,0.0002615546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004761663,"about_ca_system_score_gemma":0.0002356406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008254184,"about_ca_topic_score_gemma":0.001122317,"domain_scores_codex":[0.9998766,0.00001175267,0.00000749006,0.0000299565,0.00003546082,0.00003863288],"domain_scores_gemma":[0.9999202,0.000009101436,0.00002125757,0.00001291071,0.000007930317,0.00002854423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000051107,0.0000130447,0.0002840005,0.0000172582,0.000003037532,0.00005281935,0.00001007588,0.00006460092,0.9983828,0.0001482099,0.00002815326,0.0009449595],"study_design_scores_gemma":[0.00001226808,0.00005403589,0.01292984,0.000004948043,0.000008575254,0.0002516371,0.00004368355,0.00239382,0.9821051,0.0001406389,0.002048841,0.000006517198],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948558,0.001372947,0.002314498,0.0001218909,0.00001274331,0.00001296087,0.0001069236,0.00008605012,0.001116292],"genre_scores_gemma":[0.9970804,0.0004786204,0.0009603171,0.00002628283,0.000004964156,0.00001165961,0.0001894039,0.00001401029,0.001234283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008254184,"threshold_uncertainty_score":0.003454864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03913653545446782,"score_gpt":0.3364148542621727,"score_spread":0.2972783188077048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}