{"id":"W4404470663","doi":"10.1200/oa.24.00017","title":"Impact of Bone Metastasis in Stage IV Non–Small Cell Lung Cancer Treated With Durvalumab and Tremelimumab With or Without Chemotherapy: A Retrospective Analysis of the CCTG BR.34 Trial","year":2024,"lang":"en","type":"article","venue":"JCO oncology advances.","topic":"Cancer Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Toronto; Princess Margaret Cancer Centre; Kingston Health Sciences Centre","funders":"","keywords":"Durvalumab; Tremelimumab; Chemotherapy; Medicine; Oncology; Bone metastasis; Stage (stratigraphy); Internal medicine; Lung cancer; Retrospective cohort study; Cancer; Metastasis; Immunotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003972949,0.0002305004,0.0009852449,0.0003418041,0.0002727456,0.0008948002,0.0004270326,0.000413184,0.000642657],"category_scores_gemma":[0.006058972,0.0002302115,0.001156938,0.001138491,0.0003452272,0.0004015086,0.0003214111,0.0005663105,0.0001008542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006676831,"about_ca_system_score_gemma":0.0006884748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002062422,"about_ca_topic_score_gemma":0.003694422,"domain_scores_codex":[0.9962084,0.001834336,0.0005181289,0.0004858061,0.0007306973,0.0002225285],"domain_scores_gemma":[0.9933777,0.001866026,0.003534902,0.0005015272,0.0003353788,0.0003844154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02883167,0.000129659,0.9527343,0.0004088304,0.003136283,0.0002262224,0.00006453582,0.0004471782,0.0009859509,0.000127661,0.001136239,0.01177151],"study_design_scores_gemma":[0.00263998,0.004079808,0.9855052,0.00009951705,0.002601644,0.0008336156,0.0001001521,0.0007403517,0.0003481306,0.0001190872,0.002906645,0.00002603128],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891127,0.008304404,0.0001885423,0.0001295482,0.00003028718,0.00008649444,0.001358458,0.000004637524,0.0007849285],"genre_scores_gemma":[0.9971463,0.0007844508,0.000103161,0.0001079586,0.00005154481,0.00005845183,0.001659888,0.000005532586,0.00008258177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003972949,"threshold_uncertainty_score":0.02101123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01551241366614747,"score_gpt":0.3539318584365808,"score_spread":0.3384194447704333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}