{"id":"W4404472017","doi":"10.1101/2024.11.17.624007","title":"Inhibition of Notch Signaling Attenuates Epileptic Discharges in the Adolescent Rat Brain after Status Epilepticus Induction","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital","funders":"","keywords":"Status epilepticus; Neuroscience; Notch signaling pathway; Epilepsy; Psychology; Medicine; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009250498,0.0004567685,0.0004280589,0.0002824003,0.0001001573,0.0001331035,0.0001836521,0.0002415781,0.001054751],"category_scores_gemma":[0.0001136942,0.0001024629,0.0002127936,0.000144387,0.0001913888,0.0001943058,0.0001504056,0.0006215566,0.000172755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000123021,"about_ca_system_score_gemma":0.0002100472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005907442,"about_ca_topic_score_gemma":0.001079044,"domain_scores_codex":[0.999946,0.0000067522,0.000007650136,0.000009445287,0.00001287067,0.0000173065],"domain_scores_gemma":[0.999923,0.000005981295,0.00002530367,0.000007742334,0.0000124688,0.00002552636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001043468,0.0002716214,0.0006317636,0.0001313493,0.00002093261,0.0001462152,0.00004455248,0.00008768049,0.9908923,0.000115613,0.0001174204,0.00649701],"study_design_scores_gemma":[0.0001718449,0.005067725,0.01447011,0.00003387746,0.00008202386,0.0003694125,0.0001536704,0.001506762,0.9755859,0.0001445406,0.002403632,0.00001042218],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963303,0.001328884,0.001204787,0.00008082674,0.00003834336,0.00003686207,0.0001977173,0.00008423983,0.0006979799],"genre_scores_gemma":[0.9942924,0.001804856,0.001288917,0.00007926833,0.00001821392,0.0000939567,0.0003422169,0.00001251678,0.002067694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001054751,"threshold_uncertainty_score":0.003528535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03257638051821495,"score_gpt":0.2832424035363449,"score_spread":0.25066602301813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}