{"id":"W4404473672","doi":"10.1056/nejmoa2411790","title":"Oral Infigratinib Therapy in Children with Achondroplasia","year":2024,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stollery Children's Hospital","funders":"BridgeBio","keywords":"Achondroplasia; Medicine; Short stature; Fibroblast growth factor receptor 1; Internal medicine; Pediatrics; Endocrinology; Fibroblast growth factor; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003927321,0.00008993792,0.0001550376,0.0001391353,0.00001274003,0.00001163497,0.000118928,0.00004429465,0.000119296],"category_scores_gemma":[0.0001220863,0.00005209834,0.00002701141,0.0001681997,0.00006137806,0.000005106916,0.00001349614,0.0002298322,0.000002120424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009707443,"about_ca_system_score_gemma":0.0001845501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009077295,"about_ca_topic_score_gemma":0.0002815633,"domain_scores_codex":[0.9992967,0.00007233938,0.0001744096,0.0001151364,0.0002123176,0.0001291284],"domain_scores_gemma":[0.999679,0.00002686222,0.00003951665,0.00009325303,0.00007193541,0.00008948733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.001065402,0.00005132717,0.382466,0.00001002101,0.0002771087,0.0001378108,0.0006745164,0.00005177197,0.09148813,0.00005431238,0.0109897,0.5127339],"study_design_scores_gemma":[0.08584947,0.01976625,0.4987543,0.0006182311,0.00006451343,0.005433725,0.0004552499,0.0000825318,0.02183546,0.0006825952,0.366059,0.0003986117],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849526,0.01176589,0.0004454661,0.00224394,0.0000945406,0.00009549304,0.000001279561,0.000002863262,0.0003979217],"genre_scores_gemma":[0.9968043,0.001474324,0.0001122652,0.0001037403,0.001110151,0.000001219641,0.00001145743,0.00001344044,0.0003691122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5123353,"threshold_uncertainty_score":0.2124508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01481519150796221,"score_gpt":0.309412692660459,"score_spread":0.2945975011524968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}