{"id":"W4404473672","doi":"10.1056/nejmoa2411790","title":"Oral Infigratinib Therapy in Children with Achondroplasia","year":2024,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stollery Children's Hospital","funders":"BridgeBio","keywords":"Achondroplasia; Medicine; Short stature; Fibroblast growth factor receptor 1; Internal medicine; Pediatrics; Endocrinology; Fibroblast growth factor; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005052528,0.0003709645,0.001155303,0.0001564197,0.0003260759,0.0003310898,0.0002787011,0.0003842521,0.001252416],"category_scores_gemma":[0.0005357111,0.0001332085,0.0005885821,0.0003328295,0.0003324328,0.0002615277,0.0002434315,0.001154944,0.0002344427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008063125,"about_ca_system_score_gemma":0.001060394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001304553,"about_ca_topic_score_gemma":0.004097469,"domain_scores_codex":[0.9997048,0.00008618091,0.00002902361,0.0000507558,0.00005973188,0.00006944405],"domain_scores_gemma":[0.9995818,0.000118656,0.0001339646,0.00002345735,0.00003365671,0.0001085617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.07247692,0.007118121,0.2795516,0.003889493,0.002075156,0.009276102,0.001663501,0.006252571,0.07206853,0.001244305,0.01523906,0.5291447],"study_design_scores_gemma":[0.06721489,0.2646332,0.4715341,0.0006251014,0.002694695,0.0530751,0.001004387,0.004568561,0.03975438,0.001251154,0.09352019,0.0001241946],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984721,0.01122391,0.0005715698,0.0004462118,0.00004558497,0.0003182012,0.0005348371,0.00004941109,0.002089327],"genre_scores_gemma":[0.9934199,0.003472356,0.001442556,0.0003205324,0.00003468915,0.0002249737,0.0006208895,0.000009489186,0.000454499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001304553,"threshold_uncertainty_score":0.005850255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01481519150796221,"score_gpt":0.309412692660459,"score_spread":0.2945975011524968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}