{"id":"W4404481502","doi":"10.26685/urncst.723","title":"The Role of Synaptopathy in Alzheimer's Disease: A Review of Key Transgenic Mouse Models","year":2024,"lang":"en","type":"review","venue":"Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Genetically modified mouse; Key (lock); Neuroscience; Transgene; Disease; Biology; Medicine; Pathology; Gene; Genetics; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002610911,0.001124043,0.003052597,0.01370118,0.0003282333,0.001398833,0.001518935,0.001138445,0.002541],"category_scores_gemma":[0.004374857,0.0004903685,0.002135575,0.01062314,0.0005318309,0.001737418,0.0008396219,0.0007762756,0.0005523518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001409781,"about_ca_system_score_gemma":0.003596219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003138439,"about_ca_topic_score_gemma":0.00608452,"domain_scores_codex":[0.9990149,0.0001889858,0.0004517767,0.0001028584,0.0001987343,0.00004267657],"domain_scores_gemma":[0.9954944,0.003162894,0.0007050657,0.00006449369,0.0004921528,0.00008102191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000256019,0.00005906395,0.0006845116,0.6216691,0.001376639,0.000527022,0.000326,0.0002837796,0.003068367,0.001673753,0.008834446,0.3612414],"study_design_scores_gemma":[0.0001402276,0.0006928728,0.007798664,0.5515992,0.01540897,0.003711361,0.0004703225,0.0002587534,0.001621649,0.002789039,0.4154104,0.0000985914],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002640146,0.999099,0.0001044344,0.0001568459,0.00005792081,0.00002608438,0.00009497721,0.000005832348,0.0001909302],"genre_scores_gemma":[0.001056093,0.9983153,0.0002988262,0.0001200747,0.00003572318,0.00003613755,0.00007630959,0.000001583406,0.00005993996],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01370118,"threshold_uncertainty_score":0.01380795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06570826718256267,"score_gpt":0.4254137900817293,"score_spread":0.3597055228991666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}