{"id":"W4404498282","doi":"10.1093/neuonc/noae247","title":"Phase 2 trial of veliparib, local irradiation, and temozolomide in patients with newly diagnosed high-grade glioma: a Children’s Oncology Group study","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Sidney Kimmel Comprehensive Cancer Center; School of Medicine and Public Health, University of Wisconsin-Madison; University of Texas MD Anderson Cancer Center; Weill Cornell Medical College; Texas Children's Hospital; McGill University; Johns Hopkins University; Department of Laboratory Medicine and Pathology, University of Washington; University of Washington; St. Jude Children's Research Hospital; Massachusetts General Hospital; Memorial Sloan-Kettering Cancer Center; Syracuse University; Nationwide Children's Hospital; St. Baldrick's Foundation","keywords":"Veliparib; Temozolomide; Medicine; Internal medicine; Oncology; Radiation therapy; Interim analysis; Glioma; Chemotherapy; Clinical trial; Surgery; Poly ADP ribose polymerase; Cancer research; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002686639,0.000301777,0.0009697414,0.0005389617,0.00005426237,0.00001918111,0.00009986982,0.0002404789,0.00003645851],"category_scores_gemma":[0.0001893382,0.0002296021,0.00007994818,0.0005613128,0.0002140154,0.00009784343,0.00007416554,0.0003604118,0.00001154452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004835891,"about_ca_system_score_gemma":0.0003627724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006010968,"about_ca_topic_score_gemma":0.0007765113,"domain_scores_codex":[0.9975327,0.0004030274,0.0006877601,0.0006740923,0.0003239733,0.0003785095],"domain_scores_gemma":[0.9981855,0.001020992,0.0001896621,0.0003112435,0.00007616267,0.0002164508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0741494,0.1283661,0.5773215,0.0000987637,0.001037266,0.008159855,0.002725317,0.00006105444,0.004578224,0.0004312783,0.003151345,0.19992],"study_design_scores_gemma":[0.4149075,0.1096229,0.4708332,0.00004669459,0.0007072465,0.00009655124,0.0002071986,0.0001173959,0.0005400763,0.00003878045,0.002700901,0.0001816385],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936674,0.0003324272,0.00001634656,0.001579829,0.0007094325,0.003518994,0.00004852702,0.00006645915,0.00006057538],"genre_scores_gemma":[0.998539,0.00006232536,0.0001485615,0.000326623,0.0001978894,0.0005538761,0.0001249983,0.00004533651,0.000001426969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3407581,"threshold_uncertainty_score":0.9362903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0125536966433491,"score_gpt":0.2957024188185851,"score_spread":0.283148722175236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}