{"id":"W4404504936","doi":"10.1002/alz.14376","title":"Homocysteine, neurodegenerative biomarkers, and <i>APOE</i> ε4 in neurodegenerative diseases","year":2024,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta; Public Health Ontario; Baycrest Hospital; Toronto Western Hospital; University Health Network; Ottawa Hospital; Health Sciences Centre; Occupational Cancer Research Centre; McGill University; University of Ottawa; Ontario Brain Institute; St. Michael's Hospital; Sunnybrook Health Science Centre; Toronto Rehabilitation Institute; Montreal Neurological Institute and Hospital; Toronto Dementia Research Alliance; Western University; University of Toronto","funders":"Canadian Institutes of Health Research; HORIZON EUROPE Framework Programme; Ministry of Colleges and Universities; Olav Thon Stiftelsen; Temerty Family Foundation; Familjen Erling-Perssons Stiftelse; European Commission; Hjärnfonden; Queen's University; University of Ottawa; Canada Research Chairs; Faculty of Health Sciences, Queen's University; University College London; National Institute for Health and Care Research; London Health Sciences Foundation; Bruyère Research Institute; Government of Ontario; EU Joint Programme – Neurodegenerative Disease Research; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; Centre for Addiction and Mental Health Foundation; Baycrest Foundation; Fondation Leducq; McMaster University; Alzheimer's Drug Discovery Foundation; Ontario Brain Institute; UK Dementia Research Institute; Vetenskapsrådet; Thunder Bay Regional Health Sciences Centre","keywords":"Apolipoprotein E; Neurodegeneration; Homocysteine; Dementia; Medicine; Internal medicine; Alzheimer's disease; Disease; Psychology; Endocrinology; Oncology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001247215,0.0004639487,0.0004849332,0.00135913,0.0003961218,0.001001311,0.0003582312,0.0006556929,0.001196674],"category_scores_gemma":[0.001611962,0.0001575752,0.0004014799,0.001255053,0.000404754,0.0003554947,0.0003759117,0.0004073422,0.0001550796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003778239,"about_ca_system_score_gemma":0.0006623527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006103723,"about_ca_topic_score_gemma":0.004451821,"domain_scores_codex":[0.999666,0.0001495461,0.00004014989,0.00005802486,0.00005330193,0.00003298752],"domain_scores_gemma":[0.9990335,0.0003041504,0.0003889368,0.00004344047,0.0001180555,0.0001120263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001759021,0.00009575878,0.9722031,0.0003411619,0.0008747261,0.0004595809,0.0001475425,0.0001973163,0.001766489,0.0001966599,0.000399447,0.02155918],"study_design_scores_gemma":[0.00002020687,0.0003391148,0.9951815,0.0001444349,0.0005865296,0.0006615941,0.0001471139,0.0003098657,0.000558599,0.0008455827,0.001192794,0.00001264091],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9357023,0.06061544,0.0004014115,0.001042104,0.00006251538,0.00001892296,0.0005089049,0.00002414835,0.001624274],"genre_scores_gemma":[0.9942276,0.004584055,0.0004715123,0.0001248178,0.00006814477,0.000009356444,0.0001589699,0.000002547964,0.0003528734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006103723,"threshold_uncertainty_score":0.0121364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02457868635350428,"score_gpt":0.2987230632582222,"score_spread":0.2741443769047179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}