{"id":"W4404505793","doi":"10.1002/jcsm.13613","title":"Anabolic Sensitivity in Healthy, Lean, Older Men Is Associated With Higher Expression of Amino Acid Sensors and mTORC1 Activators Compared to Young","year":2024,"lang":"en","type":"article","venue":"Journal of Cachexia Sarcopenia and Muscle","topic":"Muscle metabolism and nutrition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"European Commission; Åke Wiberg Stiftelse","keywords":"Anabolism; Medicine; mTORC1; Sarcopenia; Lean body mass; Endocrinology; Internal medicine; Body weight; PI3K/AKT/mTOR pathway; Biochemistry; Signal transduction; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004016461,0.0001422916,0.0003325843,0.0001370701,0.0000415147,0.00003212445,0.00005264044,0.0001115027,0.00001184665],"category_scores_gemma":[0.00002894014,0.0001116358,0.00005010296,0.0001646558,0.00005195346,0.00002693155,0.00005504162,0.0001510978,3.635087e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002153283,"about_ca_system_score_gemma":0.00006235676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006422829,"about_ca_topic_score_gemma":0.00006353918,"domain_scores_codex":[0.9990053,0.0001104829,0.0002978914,0.0002164237,0.0001886946,0.0001812074],"domain_scores_gemma":[0.999467,0.00002410985,0.0001447383,0.0001114354,0.0001035972,0.0001491046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006144477,0.00009412684,0.01028019,0.00007790202,0.00005003475,0.00003913487,0.000603124,0.000009319783,0.983341,0.000009698649,0.00210656,0.002774436],"study_design_scores_gemma":[0.002287697,0.000470084,0.6247833,0.0004720613,0.00005926621,0.00006759287,0.0002774679,0.00004136327,0.3662325,0.00002612542,0.005080751,0.0002018045],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996519,0.002667931,0.00007495339,0.0003392585,0.00009747678,0.0001485143,0.00002656594,0.000004283857,0.0001220386],"genre_scores_gemma":[0.9988933,0.0005126178,0.0002005453,0.0001520181,0.0001313224,0.000002516081,0.00001043468,0.00001907941,0.00007815214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6171085,"threshold_uncertainty_score":0.4552374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01050551394463953,"score_gpt":0.2575346048543022,"score_spread":0.2470290909096627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}