{"id":"W4404505793","doi":"10.1002/jcsm.13613","title":"Anabolic Sensitivity in Healthy, Lean, Older Men Is Associated With Higher Expression of Amino Acid Sensors and mTORC1 Activators Compared to Young","year":2024,"lang":"en","type":"article","venue":"Journal of Cachexia Sarcopenia and Muscle","topic":"Muscle metabolism and nutrition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"European Commission; Åke Wiberg Stiftelse","keywords":"Anabolism; Medicine; mTORC1; Sarcopenia; Lean body mass; Endocrinology; Internal medicine; Body weight; PI3K/AKT/mTOR pathway; Biochemistry; Signal transduction; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001476476,0.0002394466,0.0003444917,0.0003349725,0.0001839906,0.000392501,0.00006395276,0.0001740187,0.002046593],"category_scores_gemma":[0.0002321917,0.0002385517,0.0002052291,0.0002187863,0.0001937256,0.0001504583,0.0001994136,0.0002127841,0.0003182006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000697369,"about_ca_system_score_gemma":0.00006079634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008240828,"about_ca_topic_score_gemma":0.0009756205,"domain_scores_codex":[0.9999382,0.000008068355,0.000004629998,0.00002494123,0.000009278937,0.00001475659],"domain_scores_gemma":[0.9998507,0.00001635589,0.00005487325,0.000009216867,0.00001139813,0.00005734889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00835254,0.0003177335,0.4924781,0.0002125583,0.0002936333,0.0009318215,0.000636547,0.0001209241,0.4815578,0.00008523934,0.0003978459,0.01461525],"study_design_scores_gemma":[0.00001991046,0.000473697,0.9971654,0.000005217647,0.00003651434,0.0002824403,0.0001260861,0.00008127797,0.001565407,0.00002398433,0.0002170569,0.000002978456],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992703,0.0003865963,0.00008423562,0.000009919736,0.000005495634,0.000002198471,0.00009153374,0.000003712487,0.0001460925],"genre_scores_gemma":[0.9989242,0.0002003923,0.00008884953,0.00003862428,0.00001230032,0.000006396976,0.0001537472,0.000002528465,0.0005730275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002046593,"threshold_uncertainty_score":0.006846488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01050551394463953,"score_gpt":0.2575346048543022,"score_spread":0.2470290909096627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}