{"id":"W4404512041","doi":"10.1002/mnfr.202400662","title":"Pterostilbene Targets Hallmarks of Aging in the Gene Expression Landscape in Blood of Healthy Rats","year":2024,"lang":"en","type":"article","venue":"Molecular Nutrition & Food Research","topic":"Phytoestrogen effects and research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; McGill University; University of British Columbia","funders":"National Institute of Food and Agriculture; National Cancer Institute; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Uniwersytet Medyczny w Lodzi; Uniwersytet Łódzki; Walther Cancer Foundation; BC Children's Hospital; Purdue University; U.S. Department of Agriculture","keywords":"Longevity; Biology; Transcriptome; Proteostasis; Pterostilbene; Phytoestrogens; Epigenetics; Gene expression; Autophagy; Genome instability; Gene; Cell biology; Genetics; Resveratrol; DNA damage; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008256792,0.0002090381,0.0002352744,0.0004501424,0.0001525602,0.0002213554,0.00007058588,0.0001717947,0.001158757],"category_scores_gemma":[0.00009675795,0.0001005608,0.0002711895,0.000361092,0.0001523611,0.0001047226,0.0001254805,0.0002609357,0.0002567608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001772085,"about_ca_system_score_gemma":0.0001727329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009452182,"about_ca_topic_score_gemma":0.001839824,"domain_scores_codex":[0.9999135,0.000006071763,0.000003618385,0.0000404114,0.00001879819,0.00001767434],"domain_scores_gemma":[0.9999312,0.000008953989,0.00002457541,0.000007002724,0.00001524514,0.00001304653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004793717,0.00002426368,0.005329467,0.00005762258,0.00002416388,0.00002691724,0.00002130322,0.00005895059,0.9889114,0.00004093702,0.00008103018,0.004944676],"study_design_scores_gemma":[0.00003072163,0.0009253771,0.3898781,0.00003526433,0.0002615654,0.0002955602,0.0002253777,0.00135773,0.6019021,0.0004010303,0.004663642,0.00002352324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989087,0.0025346,0.003097081,0.000124317,0.0000295812,0.00001321837,0.004120288,0.0001003284,0.0008934513],"genre_scores_gemma":[0.985652,0.0027083,0.003257488,0.0002731183,0.00002088053,0.00004827205,0.003920073,0.00004246082,0.004077418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001158757,"threshold_uncertainty_score":0.003876388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0411511285910387,"score_gpt":0.3764294313795017,"score_spread":0.335278302788463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}