{"id":"W4404515472","doi":"10.1016/bs.mcb.2024.10.017","title":"Retrovirus-based manufacturing of chimeric antigen receptor-modified T cells for cancer therapy research","year":2024,"lang":"en","type":"article","venue":"Methods in cell biology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"European Research Council; Hector Stiftung; Elitenetzwerk Bayern; José Carreras Leukämie-Stiftung; Ludwig-Maximilians-Universität München; Deutsche Forschungsgemeinschaft; Fritz-Bender-Stiftung; Bundesministerium für Bildung und Forschung; Deutsche Krebshilfe; Wilhelm Sander-Stiftung; Else Kröner-Fresenius-Stiftung; Bayerische Forschungsstiftung; Melanoma Research Alliance","keywords":"Biology; Retrovirus; Chimeric antigen receptor; Antigen; Cancer therapy; Virology; Cancer; Computational biology; Immunology; Cancer research; Immunotherapy; Genetics; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.006490172,0.0002152009,0.0006310118,0.0008945169,0.00006334878,0.00001898465,0.0003088533,0.0003468294,0.004188282],"category_scores_gemma":[0.0001529024,0.0001708275,0.0002228351,0.0007224722,0.0003845779,0.00002742432,0.00007329913,0.0008260353,0.00001825434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001745168,"about_ca_system_score_gemma":0.0004565369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006939073,"about_ca_topic_score_gemma":0.00002186989,"domain_scores_codex":[0.9962037,0.001629211,0.0004878783,0.0006747882,0.0002532123,0.0007512506],"domain_scores_gemma":[0.995761,0.003369001,0.00006256987,0.0005450577,0.0001481063,0.0001142215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001107048,0.00008850786,0.0005436415,0.0003025251,0.00005580925,0.000005220882,0.0002150486,0.00003691527,0.6932606,0.00003172204,0.0005918099,0.3037612],"study_design_scores_gemma":[0.001221041,0.0009331026,0.0002052722,0.00008694441,0.000007890812,7.98194e-7,0.00005735072,0.0015963,0.8117541,0.0008044454,0.1832077,0.0001250446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.936057,0.02085976,0.02298606,0.001180077,0.001820217,0.003134603,0.0001041315,0.0001253206,0.01373279],"genre_scores_gemma":[0.6833487,0.01611849,0.2854748,0.0004037801,0.000896935,0.0009354081,0.00009386391,0.0002071407,0.01252098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3036362,"threshold_uncertainty_score":0.996722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2141829973803693,"score_gpt":0.5361122738648615,"score_spread":0.3219292764844922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}