{"id":"W4404516546","doi":"10.1038/s44319-024-00320-5","title":"KMT5C leverages disorder to optimize cooperation with HP1 for heterochromatin retention","year":2024,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Cancer Foundation; Cancer Research Society; University of Alberta; Government of Alberta; Cancer Research Institute","keywords":"Heterochromatin; Heterochromatin protein 1; Biology; Linker; Computational biology; Cooperativity; Sequence motif; Genetics; Evolutionary biology; Chromatin; Computer science; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001961682,0.0003514332,0.0003049102,0.0001210174,0.0001840948,0.0003292663,0.0003979315,0.0004284908,0.0009208315],"category_scores_gemma":[0.0002658754,0.0001471373,0.0002317567,0.0001797846,0.0002710765,0.0002340448,0.0004291739,0.0005859821,0.0007062548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006169592,"about_ca_system_score_gemma":0.0002872515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001090405,"about_ca_topic_score_gemma":0.002007589,"domain_scores_codex":[0.9998559,0.00001733171,0.00001577313,0.00004185792,0.00004044208,0.00002881842],"domain_scores_gemma":[0.9999033,0.00001269783,0.0000257857,0.0000156032,0.00001177949,0.0000308648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000737971,0.00002834783,0.000396918,0.00004778957,0.000009618767,0.00008433079,0.00001534545,0.0005992654,0.9953005,0.0003405542,0.0001127651,0.002990748],"study_design_scores_gemma":[0.00001132395,0.0001314458,0.0009227234,0.000006106483,0.000009249824,0.0002491072,0.00001482333,0.003461677,0.9907469,0.00007207876,0.004362752,0.00001197025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846979,0.0006647512,0.01163564,0.0001885318,0.00004519811,0.00004105089,0.0003184104,0.0003915802,0.002016905],"genre_scores_gemma":[0.990661,0.0001903623,0.006921218,0.00009138013,0.000004561513,0.00002332867,0.0004142068,0.0001000506,0.001593931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001090405,"threshold_uncertainty_score":0.004476309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006761256302801392,"score_gpt":0.2354327821549979,"score_spread":0.2286715258521965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}