{"id":"W4404517372","doi":"10.2337/db24-0756","title":"Tracking Insulin- and Glucagon-Expressing Cells In Vitro and In Vivo Using a Double-Reporter Human Embryonic Stem Cell Line","year":2024,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"JDRF; Breakthrough T1D Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Glucagon; Embryonic stem cell; Biology; Alpha cell; Cell biology; Insulin; Stem cell; Cellular differentiation; Beta cell; Cell culture; Cell; Reporter gene; Population; Islet; Internal medicine; Endocrinology; Gene expression; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000353041,0.0003286852,0.0002293383,0.000285008,0.0001626855,0.0004117321,0.0002389041,0.0003104563,0.001219504],"category_scores_gemma":[0.0001311662,0.0002423844,0.0002189181,0.0002048244,0.0001901725,0.0002211189,0.0002819139,0.0007054029,0.0006650758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002640437,"about_ca_system_score_gemma":0.0002805013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006874537,"about_ca_topic_score_gemma":0.001131512,"domain_scores_codex":[0.9998042,0.00001673468,0.00002117884,0.00005984033,0.00007763688,0.00002049477],"domain_scores_gemma":[0.9998927,0.00002247445,0.00002275413,0.00001424686,0.00002239685,0.0000254299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001599965,0.000008246989,0.0001181422,0.00001793598,0.000001840559,0.00002345834,0.00001878663,0.00009980804,0.9978903,0.0001424485,0.00007449798,0.001588724],"study_design_scores_gemma":[0.000005072287,0.0000477943,0.0006532277,0.000005965261,0.000006020481,0.0001020924,0.00001212112,0.001967051,0.9937223,0.0000392936,0.003434526,0.000004438132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.722863,0.00231841,0.2583213,0.0003729048,0.0003290189,0.0003338826,0.002329418,0.001413936,0.0117181],"genre_scores_gemma":[0.7119929,0.003835739,0.2635983,0.0002916004,0.00006129929,0.0006203674,0.003095385,0.0004068302,0.01609757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001219504,"threshold_uncertainty_score":0.0040797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02893530129864725,"score_gpt":0.2759404095176938,"score_spread":0.2470051082190466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}