{"id":"W4404527351","doi":"10.1073/pnas.2406239121","title":"Small-molecule disruption of androgen receptor–dependent chromatin clusters","year":2024,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institutes of Health; Institute for Bioengineering and Biosciences; Kaleida Health Foundation; U.S. Department of Defense; Georgia Institute of Technology; Case Comprehensive Cancer Center, Case Western Reserve University; University at Buffalo; University of Washington; National Cancer Institute; Case Western Reserve University; Itä-Suomen Yliopisto; Perelman School of Medicine, University of Pennsylvania; Universitat de Barcelona; University of Pennsylvania; Prostate Cancer Foundation; School of Medicine, Case Western Reserve University","keywords":"Androgen receptor; Enzalutamide; Chromatin; Enhancer; Epigenome; Prostate cancer; Cancer research; Biology; Chromatin immunoprecipitation; Promoter; Cell biology; Androgen; Gene; Chemistry; Computational biology; Gene expression; Cancer; Endocrinology; Genetics; DNA methylation; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001305478,0.0002048185,0.000147165,0.0001145239,0.000165703,0.0002125409,0.0002652101,0.0001974537,0.002041016],"category_scores_gemma":[0.00007762377,0.0001387454,0.0002060072,0.0000863821,0.0002051238,0.00009520542,0.0002252848,0.0005205284,0.0003812657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002747149,"about_ca_system_score_gemma":0.000205858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006198018,"about_ca_topic_score_gemma":0.001738848,"domain_scores_codex":[0.9999176,0.00001283843,0.00000477941,0.00002338401,0.00002194597,0.00001940676],"domain_scores_gemma":[0.9999534,0.00001106608,0.00001212586,0.000006638772,0.000002904239,0.00001387399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001191372,0.00005382477,0.0000550891,0.00005599747,0.00001555277,0.00003144701,0.00001121938,0.0002880374,0.9946206,0.0006278268,0.0002526589,0.003868676],"study_design_scores_gemma":[0.000107448,0.0007271112,0.001264539,0.000008849925,0.00002040066,0.0001982577,0.00001451779,0.001869177,0.9752226,0.0001924963,0.02036504,0.000009550279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9511316,0.008374508,0.02456594,0.0006201506,0.0003543351,0.0003008408,0.001278404,0.0007356924,0.01263853],"genre_scores_gemma":[0.9868195,0.001723475,0.005510426,0.0002344439,0.00002172177,0.00009289363,0.0005784332,0.00003556763,0.004983536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002041016,"threshold_uncertainty_score":0.006827891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06388224321569005,"score_gpt":0.356030526259581,"score_spread":0.292148283043891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}