{"id":"W4404538503","doi":"10.1016/j.jcjd.2024.09.108","title":"Possible Drug Interaction Between Elexacaftor-Tezacaftor-Ivacaftor and Repaglinide","year":2024,"lang":"en","type":"article","venue":"Canadian Journal of Diabetes","topic":"Organic and Inorganic Chemical Reactions","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Medicine; Ivacaftor; Repaglinide; Drug; Pharmacology; Internal medicine; Metformin","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000194286,0.0001631248,0.0002618392,0.0001947588,0.0001095339,0.0002157342,0.0001900356,0.0001331062,0.001764897],"category_scores_gemma":[0.0003644677,0.0001499452,0.0001281127,0.0001779405,0.00009423635,0.0004230231,0.00001919013,0.0006243966,0.00004810581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003367721,"about_ca_system_score_gemma":0.0007249268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002809448,"about_ca_topic_score_gemma":0.00005026017,"domain_scores_codex":[0.9988536,0.00001363244,0.0004407631,0.0002015829,0.0001474502,0.0003430196],"domain_scores_gemma":[0.9985269,0.0003026966,0.0001249402,0.0001653289,0.00009413031,0.0007859879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000005431688,0.00003258885,0.4596513,0.0005821235,0.0008335052,0.000106698,0.000230324,0.000001472565,0.4210667,0.0005465011,0.06635859,0.05058474],"study_design_scores_gemma":[0.000510012,0.00008359149,0.02820821,0.001381291,0.0004530808,0.00006320044,0.001183389,0.0001083858,0.4585564,0.002062826,0.5067708,0.0006186963],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901134,0.005039567,0.000003832202,0.0003743629,0.000105903,0.00002154608,0.00005566293,0.00003386566,0.004251841],"genre_scores_gemma":[0.9969843,0.00006751602,0.00007307186,0.00007581792,0.00136954,0.000001173707,0.00000979562,0.00003806989,0.001380694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4404123,"threshold_uncertainty_score":0.9991477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009964416572896866,"score_gpt":0.2324653557248065,"score_spread":0.2225009391519097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}