{"id":"W4404539804","doi":"10.1016/j.jcjd.2024.09.008","title":"Cytotoxic T-Cell Injury Drives Beta Cell Senescence Entry in Type 1 Diabetes","year":2024,"lang":"en","type":"article","venue":"Canadian Journal of Diabetes","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Research Manitoba","funders":"","keywords":"Medicine; Cytotoxic T cell; BETA (programming language); Senescence; Beta cell; Cell; Diabetes mellitus; Internal medicine; Endocrinology; Genetics; In vitro; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002102182,0.0002406674,0.0003084574,0.0003904646,0.0004084626,0.000843176,0.0002251672,0.0003176126,0.001936737],"category_scores_gemma":[0.0002228403,0.0002168753,0.0002655504,0.0002442053,0.0002852086,0.000254716,0.0003393534,0.0008025683,0.000399161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00099784,"about_ca_system_score_gemma":0.0006483544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006614653,"about_ca_topic_score_gemma":0.009243915,"domain_scores_codex":[0.999796,0.0000240627,0.00001181886,0.00002440399,0.00005418844,0.00008958129],"domain_scores_gemma":[0.9998511,0.00002103797,0.00003740063,0.00001348156,0.00002704985,0.00004983843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007730142,0.0001012778,0.003005693,0.00006232125,0.000006382871,0.0005326343,0.0001342731,0.0000827684,0.9920122,0.0003914723,0.00024439,0.002653494],"study_design_scores_gemma":[0.0002351816,0.001879293,0.3002731,0.00009301447,0.00009199775,0.003472058,0.00231697,0.00279496,0.6766362,0.001439828,0.01071707,0.00005036135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963962,0.001199706,0.0003197352,0.000135212,0.00003832027,0.00001252165,0.0001223514,0.00003835263,0.001737458],"genre_scores_gemma":[0.9970198,0.000745605,0.0001783703,0.00006217402,0.00001821605,0.00000862111,0.00011148,0.0000108762,0.001844857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006614653,"threshold_uncertainty_score":0.0131523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003695689789345811,"score_gpt":0.1977985530489239,"score_spread":0.1941028632595781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}