{"id":"W4404552777","doi":"10.3389/fimmu.2024.1493878","title":"HLA class, calcineurin inhibitor levels, and the risk of graft failure in kidney recipients with de novo donor-specific antibodies","year":2024,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Calcineurin; Antibody; Human leukocyte antigen; Medicine; Donor specific antibodies; Immunology; Tacrolimus; Kidney transplantation; Graft rejection; Kidney; Transplantation; Antigen; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009704142,0.0002553989,0.0003016168,0.0005476017,0.0002370381,0.0005458338,0.0002495947,0.0004290082,0.00129753],"category_scores_gemma":[0.00280878,0.0002143015,0.0003138641,0.0004766985,0.0002322196,0.0003342241,0.0002675955,0.0005498292,0.0001745869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001877924,"about_ca_system_score_gemma":0.0002235135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009131213,"about_ca_topic_score_gemma":0.0007560563,"domain_scores_codex":[0.9997095,0.00009310099,0.00003178877,0.00005124695,0.00005766737,0.0000565864],"domain_scores_gemma":[0.997386,0.0007970671,0.00116711,0.0001134611,0.0001140616,0.0004222765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001926838,0.00001750644,0.9988977,0.000003129541,0.00001825546,0.00003799053,0.00001002353,0.00003040817,0.0001102042,0.000005094568,0.00001334935,0.0006636999],"study_design_scores_gemma":[0.00001196664,0.0002237844,0.9984085,0.000003798248,0.00004020825,0.0007204908,0.00003634131,0.0003342178,0.0001318719,0.00002618862,0.00005954972,0.000003193411],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996243,0.0002127228,0.00003787662,0.00001137328,0.000001718794,0.00000126317,0.00002634547,0.000001332341,0.00008313233],"genre_scores_gemma":[0.9998566,0.0000429759,0.0000259903,0.000005666349,0.000005219583,0.000001065547,0.00003070181,5.642285e-7,0.00003116724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00129753,"threshold_uncertainty_score":0.005132079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009850966674982902,"score_gpt":0.2455481246031484,"score_spread":0.2356971579281655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}