{"id":"W4404558046","doi":"10.1139/cjm-2024-0155","title":"Carvacrol, a monoterpenoid, binds quorum sensing proteins (LasI and LasR) and swarming motility protein BswR of <i>Pseudomonas aeruginosa,</i> resulting in loss of pathogenicity: an in silico approach","year":2024,"lang":"en","type":"article","venue":"Canadian Journal of Microbiology","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Quorum sensing; Biofilm; Carvacrol; Pseudomonas aeruginosa; Swarming motility; Microbiology; In silico; Docking (animal); Chemistry; Ligand (biochemistry); Biology; Bacteria; Biochemistry; Receptor; Antimicrobial; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001909151,0.0008382921,0.000866821,0.0003670435,0.0006403829,0.0005870797,0.000896759,0.0007334352,0.004946354],"category_scores_gemma":[0.0003401144,0.000452541,0.00091765,0.0003083716,0.0002390209,0.000421874,0.0003773624,0.000757229,0.0005064066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007145416,"about_ca_system_score_gemma":0.0009702154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008222574,"about_ca_topic_score_gemma":0.009404172,"domain_scores_codex":[0.9998773,0.00002366939,0.000005497106,0.00002151233,0.00003458315,0.00003746444],"domain_scores_gemma":[0.9998504,0.00007682086,0.0000211112,0.00000550363,0.00002364669,0.00002256357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0009621183,0.0006646433,0.01197835,0.001044189,0.0004302514,0.001081574,0.0001473204,0.8657704,0.1019125,0.003617338,0.001772136,0.01061922],"study_design_scores_gemma":[0.0001367057,0.0008251741,0.002113172,0.00004602038,0.0001543357,0.0001179637,0.0001304521,0.9734085,0.0197568,0.000670471,0.0026016,0.00003872305],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822477,0.001735154,0.006351109,0.000315877,0.000061776,0.00005249149,0.001191705,0.0001979182,0.007846234],"genre_scores_gemma":[0.9881356,0.00144153,0.006451046,0.0001446779,0.00001818762,0.0001142684,0.001822518,0.00003990407,0.00183225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008222574,"threshold_uncertainty_score":0.0165472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008068467738108213,"score_gpt":0.2099943941973123,"score_spread":0.2019259264592041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}