{"id":"W4404563689","doi":"10.1126/scitranslmed.adn8388","title":"Monoclonal antibodies that block Roundabout 1 and 2 signaling target pathological ocular neovascularization through myeloid cells","year":2024,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Yale University; National Institutes of Health; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; American Heart Association","keywords":"Cell biology; Cancer research; Biology; Immunology; Neovascularization; Angiogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001601361,0.0006235856,0.0003250349,0.0003698589,0.000143304,0.0002343636,0.0002332506,0.0003537754,0.001251162],"category_scores_gemma":[0.0001187629,0.0001759746,0.0003395189,0.0001103175,0.0001697952,0.0001902153,0.000128324,0.0006050931,0.0003192897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003442224,"about_ca_system_score_gemma":0.000267324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000525546,"about_ca_topic_score_gemma":0.001239692,"domain_scores_codex":[0.9997953,0.00002256904,0.00001917793,0.0000452263,0.00005027055,0.00006751546],"domain_scores_gemma":[0.9999084,0.00001748668,0.00003229592,0.000009212759,0.00001361773,0.00001901172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005266747,0.00003623026,0.00008883946,0.00003657442,0.000008159433,0.00003141384,0.000008216537,0.00004539717,0.9977809,0.0001025526,0.00007778746,0.001731226],"study_design_scores_gemma":[0.00005466044,0.0006014131,0.002348421,0.000007801589,0.00004423507,0.0003774441,0.00001001657,0.0006028056,0.9904301,0.00005346735,0.005464231,0.000005388996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9771011,0.005667544,0.01236763,0.0002638359,0.0001323034,0.0002002,0.0004422283,0.0003649494,0.003460112],"genre_scores_gemma":[0.9788862,0.004133247,0.01104546,0.000269325,0.00006879997,0.0002419718,0.001149864,0.00005911356,0.004146074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001251162,"threshold_uncertainty_score":0.004185557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03246109580988171,"score_gpt":0.314305378134827,"score_spread":0.2818442823249452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}