{"id":"W4404564780","doi":"10.51731/cjht.2024.1028","title":"Avapritinib (Ayvakyt)","year":2024,"lang":"en","type":"article","venue":"Canadian Journal of Health Technologies","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Systemic mastocytosis; Medicine; Cutaneous Mastocytosis; Internal medicine; Oncology; Bone marrow","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003387599,0.0003718873,0.0007317366,0.0006366377,0.000380364,0.0007345512,0.0005118111,0.0009169504,0.0149949],"category_scores_gemma":[0.0003893534,0.0001320388,0.0005789663,0.000345761,0.0002330899,0.0004386835,0.0004584969,0.001588495,0.006652059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00124293,"about_ca_system_score_gemma":0.001025718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004019239,"about_ca_topic_score_gemma":0.01051308,"domain_scores_codex":[0.99976,0.00003020287,0.00001575241,0.00005490941,0.00008064029,0.00005845311],"domain_scores_gemma":[0.9998457,0.0000161066,0.00002447674,0.000009740531,0.00003394666,0.00006993839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003602425,0.0008137343,0.003101601,0.001809336,0.0002522734,0.00134432,0.00007629646,0.001331076,0.03495156,0.003573954,0.1951207,0.7540228],"study_design_scores_gemma":[0.009247037,0.005749207,0.01665541,0.0004794614,0.0002461383,0.01412411,0.0000825674,0.002429276,0.02365014,0.002223166,0.9250244,0.00008907093],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.2424335,0.3301392,0.008830779,0.02615576,0.004742343,0.001941985,0.01504688,0.006813063,0.3638966],"genre_scores_gemma":[0.8035572,0.04973422,0.006272556,0.008539776,0.0008579232,0.0006992155,0.01950469,0.0002009922,0.1106334],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.0149949,"threshold_uncertainty_score":0.05016291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01671379464688355,"score_gpt":0.2494976186698711,"score_spread":0.2327838240229875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}