{"id":"W4404566625","doi":"10.1038/s41586-024-08247-6","title":"Liver X receptor unlinks intestinal regeneration and tumorigenesis","year":2024,"lang":"en","type":"article","venue":"Nature","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium","funders":"","keywords":"Biology; Liver X receptor; Carcinogenesis; Cell biology; Regeneration (biology); CYP27A1; Intestinal epithelium; Cancer research; Downregulation and upregulation; Cancer; Transcription factor; Epithelium; Nuclear receptor; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003589443,0.0004262024,0.0004150981,0.0005709744,0.0001973622,0.0005891027,0.0001595704,0.0003095504,0.001037719],"category_scores_gemma":[0.0002465996,0.0002216701,0.0003066372,0.0003480134,0.0003473342,0.0002827292,0.0004862188,0.0005333097,0.0005361221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003078795,"about_ca_system_score_gemma":0.0003195446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002688489,"about_ca_topic_score_gemma":0.0005009873,"domain_scores_codex":[0.9995503,0.00005737941,0.00003065739,0.0001681517,0.0001364213,0.00005706274],"domain_scores_gemma":[0.9996309,0.00004777755,0.0001955279,0.0000572523,0.00002584233,0.00004263887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008369984,0.000007557293,0.001615521,0.00007528163,0.00001869339,0.00005770436,0.00001133738,0.0001621835,0.9953112,0.00009474427,0.00006015625,0.00250195],"study_design_scores_gemma":[0.0000136042,0.0003062754,0.06549013,0.00003209649,0.00007362404,0.001208132,0.00009823502,0.003981538,0.9175953,0.0006956575,0.0104913,0.00001411639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806901,0.006686959,0.008739794,0.0002613316,0.0000406572,0.00003233577,0.001581087,0.0004955769,0.001472122],"genre_scores_gemma":[0.9868874,0.002413544,0.005273206,0.0001808419,0.00003299881,0.00002782056,0.002765526,0.00008044482,0.002338233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001037719,"threshold_uncertainty_score":0.003471494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008425996751797626,"score_gpt":0.2421632954937601,"score_spread":0.2337372987419625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}