{"id":"W4404567435","doi":"10.1099/acmi.0.000958.v1","title":"Whole-genome sequencing of the Streptomyces coelicolor bldA39 mutant (J1700) of reveals hundreds of previously unknown mutations.","year":2024,"lang":"en","type":"preprint","venue":"","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal College of Physicians and Surgeons of Canada","funders":"Royal Academy of Engineering; Leverhulme Trust","keywords":"Streptomyces coelicolor; Genetics; Biology; Genome; Whole genome sequencing; Streptomyces; Gene; Transfer RNA; Mutant; Computational biology; RNA; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001462808,0.0006066608,0.0003437267,0.0005455496,0.0002702822,0.0004139865,0.0002231794,0.0004077896,0.001620093],"category_scores_gemma":[0.0002463599,0.0001607263,0.0004646932,0.001030034,0.0001436745,0.0001259721,0.0002467539,0.0005953781,0.001427145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002680769,"about_ca_system_score_gemma":0.0004438673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003394716,"about_ca_topic_score_gemma":0.006402123,"domain_scores_codex":[0.9998753,0.000008284036,0.000009070838,0.00003661951,0.00005252641,0.00001809793],"domain_scores_gemma":[0.9998581,0.00002219658,0.00003540269,0.00001953489,0.00002554972,0.00003923102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001732997,0.0000249461,0.001359,0.0001232278,0.00002172723,0.0002508391,0.00005281836,0.0001402771,0.9899309,0.0001305832,0.0009577847,0.006834506],"study_design_scores_gemma":[0.00007506632,0.000563572,0.1710643,0.00007890755,0.000167683,0.003353857,0.0003808447,0.00235497,0.7343668,0.000578792,0.08694705,0.00006826249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8512083,0.002633974,0.0188049,0.0003949985,0.0002338164,0.0001215016,0.1180184,0.001385865,0.007198423],"genre_scores_gemma":[0.6565417,0.003236723,0.05199756,0.0003225859,0.00004668043,0.0001344362,0.2750629,0.00121326,0.01144421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003394716,"threshold_uncertainty_score":0.006749928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02473350663865453,"score_gpt":0.2740162442735433,"score_spread":0.2492827376348888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}