{"id":"W4404568161","doi":"10.3389/fnmol.2024.1443985","title":"Peptide discovery across the spectrum of neuroinflammation; microglia and astrocyte phenotypical targeting, mediation, and mechanistic understanding","year":2024,"lang":"en","type":"review","venue":"Frontiers in Molecular Neuroscience","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Neuroinflammation; Microglia; Neuroscience; Astrocyte; Biology; Phenotype; Neurodegeneration; Context (archaeology); Immune system; Inflammation; Central nervous system; Immunology; Medicine; Pathology; Genetics; Disease; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004338262,0.000944372,0.000973024,0.00198457,0.0002244778,0.0008844319,0.0006996438,0.000895582,0.002184221],"category_scores_gemma":[0.0004452776,0.0002844564,0.0003287786,0.001934172,0.0004775128,0.001208787,0.000582687,0.001752484,0.002000066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005515453,"about_ca_system_score_gemma":0.0007577257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005042749,"about_ca_topic_score_gemma":0.0007735607,"domain_scores_codex":[0.9998556,0.00002027542,0.00001625524,0.00002799866,0.0000619193,0.0000180441],"domain_scores_gemma":[0.9998701,0.00005092974,0.00001917607,0.000005751757,0.00003582706,0.00001811835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001191679,0.0001295839,0.000149946,0.01816211,0.00007878913,0.000374379,0.00008917402,0.0007197266,0.01670099,0.01035346,0.02986904,0.9232537],"study_design_scores_gemma":[0.00001813533,0.0001482859,0.0005181475,0.001946265,0.00006171127,0.001440799,0.0000424198,0.0001513676,0.004277101,0.002443184,0.9889303,0.00002223327],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004247098,0.9960834,0.0005560908,0.0002167798,0.0002856027,0.00001111234,0.00003913327,0.00002061891,0.002362583],"genre_scores_gemma":[0.001475907,0.9965162,0.0004908739,0.0001800576,0.0001455872,0.00001700535,0.000048655,0.000003390399,0.001122315],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002184221,"threshold_uncertainty_score":0.007306933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03499100563445924,"score_gpt":0.2935698556845883,"score_spread":0.2585788500501291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}