{"id":"W4404578607","doi":"10.1101/2024.11.20.624566","title":"Targeting the translation initiation complex in therapy-resistant and metastatic melanoma","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; University of British Columbia; McGill University","funders":"","keywords":"Translation (biology); Melanoma; Cancer research; Medicine; Biology; Genetics; Messenger RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004685691,0.0002698931,0.0002269721,0.0001001941,0.00009764471,0.0001245714,0.0002232032,0.0001656629,0.0000072119],"category_scores_gemma":[0.00004992607,0.0002234081,0.00006651446,0.0002133836,0.00008522295,0.000005273756,0.0001958132,0.0003015969,0.000006895894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001983852,"about_ca_system_score_gemma":0.0001601979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004110322,"about_ca_topic_score_gemma":0.00001031774,"domain_scores_codex":[0.9985977,0.0001398215,0.0003511663,0.0005418982,0.0001376279,0.0002317978],"domain_scores_gemma":[0.9992109,0.00003022334,0.0001441687,0.0004745479,0.00008035481,0.00005982029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002209313,0.00003562543,0.0003772876,0.00007968971,0.00006033272,0.000002926358,0.00001657495,0.00004589725,0.9986803,0.0005347677,0.0001183637,0.00002611884],"study_design_scores_gemma":[0.001573594,0.000125416,0.1395034,0.0002374405,0.000281529,7.063721e-8,0.00003255897,0.004644437,0.7904508,0.0001654162,0.06164176,0.001343674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977457,0.01986037,0.0009506999,0.0005926045,0.0001768236,0.0006851477,0.0002204702,0.00004312357,0.00001371753],"genre_scores_gemma":[0.9955435,0.001671439,0.00200414,0.0001806646,0.0002584906,0.0002776216,0.000007056885,0.00005482086,0.000002249606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2082296,"threshold_uncertainty_score":0.9110316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02473709656846323,"score_gpt":0.2512706219986231,"score_spread":0.2265335254301599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}