{"id":"W4404587345","doi":"10.7554/elife.96085.3","title":"ACK1 and BRK non-receptor tyrosine kinase deficiencies are associated with familial systemic lupus and involved in efferocytosis","year":2024,"lang":"en","type":"article","venue":"eLife","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"Core Research for Evolutional Science and Technology; National Institute of Allergy and Infectious Diseases; Japan Society for the Promotion of Science; Fondation pour la Recherche Médicale; Assistance Publique - Hôpitaux de Paris; Arthritis Research UK","keywords":"Efferocytosis; MERTK; Immunology; Tyrosine kinase; Systemic lupus erythematosus; Autoantibody; Autoimmunity; Medicine; Biology; Immune system; Cancer research; Receptor tyrosine kinase; Macrophage; Kinase; Cell biology; Signal transduction; Disease; Antibody; Internal medicine; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002416385,0.0001766749,0.0003140678,0.0001414688,0.0001165944,0.00005211167,0.00006982044,0.0001982472,0.00001634419],"category_scores_gemma":[0.0000848191,0.0001351684,0.00003029502,0.0002339324,0.0001633807,0.0001343657,0.00006541499,0.0001881942,0.0000415371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008873022,"about_ca_system_score_gemma":0.0000445401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009686359,"about_ca_topic_score_gemma":0.0001642087,"domain_scores_codex":[0.999057,0.0001075958,0.0002294155,0.0003032503,0.00005083561,0.0002518957],"domain_scores_gemma":[0.9996019,0.0001383396,0.00006874774,0.0001221535,0.00004696871,0.00002190477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001563086,0.00006897984,0.1646514,0.0001343952,0.000115141,0.000007700434,0.001155969,0.000008481814,0.830781,0.00007362961,0.001614434,0.001232527],"study_design_scores_gemma":[0.004652068,0.0006082452,0.7704384,0.0029196,0.0001561072,0.0001655467,0.002346941,0.0005831023,0.2151626,0.00001538142,0.002329177,0.0006228944],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9688156,0.03017655,0.00002566771,0.0001124553,0.0004940354,0.0002290342,0.00004224277,0.00007169945,0.00003272915],"genre_scores_gemma":[0.9987665,0.0005391695,0.00001105655,0.00006293508,0.00002163879,0.00002828661,0.00009656451,0.0000176345,0.0004562481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6156185,"threshold_uncertainty_score":0.5512007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01103139601536278,"score_gpt":0.215812394402026,"score_spread":0.2047809983866632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}