{"id":"W4404587345","doi":"10.7554/elife.96085.3","title":"ACK1 and BRK non-receptor tyrosine kinase deficiencies are associated with familial systemic lupus and involved in efferocytosis","year":2024,"lang":"en","type":"article","venue":"eLife","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"Core Research for Evolutional Science and Technology; National Institute of Allergy and Infectious Diseases; Japan Society for the Promotion of Science; Fondation pour la Recherche Médicale; Assistance Publique - Hôpitaux de Paris; Arthritis Research UK","keywords":"Efferocytosis; MERTK; Immunology; Tyrosine kinase; Systemic lupus erythematosus; Autoantibody; Autoimmunity; Medicine; Biology; Immune system; Cancer research; Receptor tyrosine kinase; Macrophage; Kinase; Cell biology; Signal transduction; Disease; Antibody; Internal medicine; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003539229,0.001609132,0.0004553385,0.001317927,0.0004143756,0.0003386288,0.0003150381,0.000976474,0.002470556],"category_scores_gemma":[0.0007315428,0.00026401,0.0003553692,0.0006303408,0.0006398165,0.0002630048,0.0004248601,0.000491787,0.0002867781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002360046,"about_ca_system_score_gemma":0.0001586802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001002217,"about_ca_topic_score_gemma":0.0008598165,"domain_scores_codex":[0.9995052,0.00009720851,0.00009020772,0.000154117,0.00009650226,0.00005676864],"domain_scores_gemma":[0.9992926,0.0001345242,0.000412604,0.0000350461,0.00003345331,0.0000916767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005515299,0.0002342362,0.2286619,0.0003465919,0.000500443,0.07473214,0.0007066793,0.000870029,0.6713784,0.001337343,0.0007833066,0.01493356],"study_design_scores_gemma":[0.0002883605,0.0009379403,0.6358936,0.0001290462,0.0007560397,0.2702341,0.0004115007,0.002864005,0.08265667,0.001049987,0.00470701,0.00007170075],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978917,0.0006574368,0.0007336878,0.00009388871,0.000009627699,0.000006283586,0.0001602575,0.00003770601,0.0004093484],"genre_scores_gemma":[0.9986772,0.0002320652,0.0005111229,0.00003491353,0.00001884595,0.000003133228,0.0001244356,0.000009218455,0.0003890232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002470556,"threshold_uncertainty_score":0.00826484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01103139601536278,"score_gpt":0.215812394402026,"score_spread":0.2047809983866632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}