{"id":"W4404587478","doi":"10.1016/j.immuni.2024.10.015","title":"Cancer cells restrict immunogenicity of retrotransposon expression via distinct mechanisms","year":2024,"lang":"en","type":"article","venue":"Immunity","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Université de Montréal","funders":"National Institute of General Medical Sciences; National Institute on Aging; Canadian Institutes of Health Research; Dystonia Medical Research Foundation Canada; V Foundation for Cancer Research; Stanford Genome Technology Center; Mark Foundation For Cancer Research; Memorial Sloan-Kettering Cancer Center; Fondation pour la Recherche Médicale; National Institutes of Health; Consejo Nacional de Ciencia y Tecnología; Pershing Square Sohn Cancer Research Alliance; National Cancer Institute; Jane Coffin Childs Memorial Fund for Medical Research; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute","keywords":"Biology; Retrotransposon; Immunogenicity; Cancer; Computational biology; Cancer research; Genetics; Virology; Gene; Immune system; Transposable element; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004609667,0.0004608593,0.0004637396,0.0004487883,0.0002523657,0.001149418,0.0003130328,0.0004938,0.002041787],"category_scores_gemma":[0.0004372637,0.0001887534,0.0004430506,0.0001910158,0.0003933016,0.0005053036,0.0005799858,0.0009885657,0.0005848938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003769506,"about_ca_system_score_gemma":0.0002552081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002743317,"about_ca_topic_score_gemma":0.0003612281,"domain_scores_codex":[0.9993163,0.0001546131,0.00004293302,0.00009034442,0.0001773023,0.0002186078],"domain_scores_gemma":[0.999509,0.0001704906,0.00006685428,0.00009649858,0.00009804991,0.00005917513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001888915,0.0000807759,0.0007486194,0.00008413989,0.00001623226,0.00004749857,0.00009971335,0.0001100855,0.9906523,0.002139632,0.0001049467,0.005727277],"study_design_scores_gemma":[0.00006220192,0.0009481098,0.009289704,0.00003934034,0.00005405424,0.0004854824,0.0002771078,0.00170641,0.9784525,0.0006139384,0.00805898,0.00001228516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776715,0.007035267,0.007420165,0.0002090623,0.00009533401,0.0001192952,0.0001280588,0.0001051942,0.007216136],"genre_scores_gemma":[0.9951994,0.001061289,0.001151168,0.00009156522,0.00003614761,0.00005173031,0.0001272483,0.00001657238,0.002264844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002041787,"threshold_uncertainty_score":0.006830454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03023688800305665,"score_gpt":0.3313843503377144,"score_spread":0.3011474623346577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}